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Immunomonitoring of Cyclosporin A in healthy volunteers

This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…

The PaPa Trial: Paracetamol as an adjunct to intraPartum Remifentanil/PCA. An RCT of multimodal pain management during labor.

Adding Paracetamol to treatment with Remifentanil/ Patient Controlled Analgesia for management of labour pain ("multimodal pain management") reduces opioid (Remifentanil) consumption

The effect of protein hydrolysate supplementation to preserve muscle mass during immobilisation and enhance muscle regain during recovery

We hypothesize that protein hydrolysate supplementation will attenuate the loss in muscle mass during 7 days of immobilisation and will augment the rate of muscle mass re-gain during recovery.

Thuis in de opvang: Een fijne start voor baby’s

The intervention will result in: - higher observed sensitivity and more positive attitudes towards sensitive caregiving in professional caregivers - lower cortisol levels, higher wellbeing and more attachment security in infants - less separation…

Elucidating the therapeutic mechanism of DBS

This is an exploratory pilot study without specific hypotheses.

Brain Stimulation for Mental Control

A combined tDCS-working memory intervention in healthy military personnel strengthens self-regulation under threat via effects on DLPFC-linked neural activity.

Peroperative administration of tranexamic acid in sleeve gastrectomy

When administering tranexamic acid during induction of the procedure, there will be less usage of hemostatic clips. Also, postoperatively, patients will have less decrease in hemoglobin value and lesser reinterventions because of hemorrhage will be…

Cognitive Bias Modification: Exploring the effects of a computer-based cognitive bias training in oncology patients at risk for depression and anxiety symptoms -(OncoCogTrain)

The purpose of our study is to test the effect of a computer-based cognitive behavioral intervention (called Cognitive Bias Modification, CBM) on affective symptoms in oncology patients. Here we are collaborating with the Oncology department of the…

To examine the effect of dietary supplementation with fish oils and complex lipids on mitochondrial, physical, and cognitive function, in elderly humans.

The main objective of this study is to determine whether supplementation with FO combined with complex phospholipids can alter skeletal muscle mitochondrial function more effectively than FO alone. Additional exploratory objectives are;…

The effect of short-term Aronia melanocarpa extract supplementation on cognitive function in healthy young adults

With this research we look at the short-term effects of an aronia malanocarpa extract on cognitive functioning in healthy young adults compared to placebo.

A Phase IIb Randomized, Double-blind, Parallel Group, Placebo- and Active-controlled Study with Double-Blind Extension to Assess the Efficacy and Safety of Vamorolone in Ambulant Boys with Duchenne Muscular Dystrophy (DMD)

Primary objectives: 1. To compare the efficacy of vamorolone administered orally at daily doses of 6.0 mg/kg over a 24-week treatment period vs. placebo in ambulant boys ages 4 to <7 years with DMD; and2. To evaluate the safety and…

The effect of probiotics on gastrointestinal symptoms during endurance exercise and exercise performance in relation to the composition of the gut microbiota/metabolites.

Primary Objective: Can the chance at and/or intensity of gastrointestinal symptoms during exercise be influenced by probiotics supplementation in recreationally trained endurance athletes who experience these symptoms and can performance be enhanced…

A phase IIa, placebo-controlled, double blind, randomised multicentre pilot study to investigate the efficacy, safety and tolerability of the monoclonal antibody ATH3G10 in patients with ST-elevation myocardial infarction

The main goal of this study is to evaluate efficacy of a single administration of ATH3G10 in patients presenting with an acute STEMI undergoing PCI.The primary objective is to investigate effects on left ventricular remodelling as measured by the…

Randomized, Double-blind, Placebo-controlled, Two-Part, Adaptive Design Study of Safety, Tolerability, Preliminary Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Oral Doses of MYK-491 in Patients with Stable Heart Failure with Reduced Ejection Fraction

To establish preliminary safety and tolerability of single- and multiple-ascending oral doses of MYK 491 in ambulatory patients with stable heart failure with reduced ejection fraction (HFrEF)

Brain Stimulation for Mental Control

The study objective is to test the effect of a tDCS intervention in a sample of healthy military personnel. We investigate the effects of the intervention primarily on the intensity of fear reactions, and secondarily on cognitive performance and…

A randomized, placebo-controlled, double-blind, parallel arms study to evaluate the pharmacokinetic and pharmacodynamic relationship of multiple subcutaneous injections of apraglutide in healthy volunteers.

1. A better understanding of the apraglutide dose/concentration-effect relationship;2. A better understanding of duration of effect (apraglutide kinetics in relation to citrulline kinetics).

A randomized, double-blind, double-dummy, placebo-controlled, 3-way crossover proof of concept study of intradermally administered desmopressin in healthy volunteers using a nanoporous microneedle array.

1) To evaluate the safety and tolerability of MLT*s npMNAs2) To evaluate the pharmacokinetics of intradermal desmopressin administration via MLT*s npMNAs

Randomized, placebo-controlled study to immunomonitor Mycophenolate mofetil (MMF) in healthy volunteers

Objective(s)* To investigate the pharmacokinetic behaviour of a single dose of MMF;o Plasma concentrationso Cellular concentrationso Relationship between plasma and cellular concentrations* To investigate the pharmacodynamic effects of a single dose…

A Safety, Tolerability, Pharmacokinetic, and Pilot Food Effect Study of Single- and Multiple-Ascending Doses of LY3526318 in Healthy Participants

Primary (Part A)To evaluate safety and tolerability of LY3526318 in healthy participants following a single oral dosePrimary (Part B)To evaluate safety and tolerability of LY3526318 in healthy participants following multiple once-daily oral doses…

A Randomized, Double-Blind, Double-Dummy, Active Controlled Study to Evaluate the
Safety, Tolerability, Pharmacokinetics, and Efficacy of ABBV-3373 in Subjects with Moderate to Severe
Rheumatoid Arthritis

1. To assess the safety, tolerability, and efficacy of ABBV-3373 administered every other week (eow) intravenously (IV) in subjects with moderately to severely active RA on background MTX.2. To compare clinical efficacy of ABBV-3373 with adalimumab…