21 results
To test whether tACS in a theta frequency enhances extinction of physiological stress responses to exposure to anxiety- or trauma-related stimuli or memories. Secondarily, to examine the influence of baseline neuroendocrinological response, baseline…
We aim to lay the fundament of novel interventions by gaining an in-depth comprehensive understanding of individual differences in the overnight adaptation of emotional memory and malleability thereof by noradrenergic modulation.
The aim of the study is to investigate whether standardized or personalized tACS induces EEG changes indicative of delirium reversal (primary outcome) or reduces the duration and/or severity of delirium (secondary outcome) compared to sham treatment…
To assses safety, gut engraftment and effects on sugar- and alcohol metabolism of d. piger in individuals with increased waist circumference.
Primary objective: to study whether pyridoxamine supplementation in type 2 diabetes improves microvascular function in the eye, kidney and skin, and reduces markers of endothelial dysfunction and glycation.Secondary objective: to study whether…
Primary: To determine the efficacy and safety of bel-sar compared to sham control for thetreatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).Secondary: To assess the systemic pharmacokinetics (PK) and immunogenicity of…
Primary: To determine the efficacy and safety of bel-sar compared to sham control for thetreatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).Secondary: To assess the systemic pharmacokinetics (PK) and immunogenicity of…
The aim of the two separate studies is as follows: 1. To evaluate the effect of perioperative micronised lipofilling in patients with ORIF of P1 fractures on postoperative range of motion2. To evaluate the effect of perioperative micronised…
Primary Objective: • To assess whether the food supplement Endocalyx lowers blood pressure in patients with treatment resistant hypertension.Secondary Objectives: • To study the effect of Endocalyx on office blood pressure and 24-hour blood pressure…
To study the efficacy of preoperative CBM in patients with increased anxiety levels undergoing knee- or spine surgery with expected postoperative moderate to severe pain.
To assess whether 10 sessions of cTBS of the contralesional primary motor cortex combined with regular care upper limb training, started within three weeks after stroke onset, are effective and cost effective in promoting upper limb recovery after…
The primary objective is to evaluate in older men the acute effect of ketone monoester supplementation on (regional) brain vascular function and insulin-sensitivity, as quantified by the non-invasive gold standard magnetic resonance imaging (MRI)-…
The primary goal is to demonstrate that in gastric esophageal cancer the addition of a microbiome intervention with fecal capsules from healthy donors can improve the effectiveness of perioperative chemotherapy as measured by the tumor regression…
IVD1: The primary objective of this clinical performance study is to evaluate the effectiveness of the MyChoice® test in identifying HRRm or non-HRRm mCSPC patients as part of the enrolment criteria for EvoPAR-prostate01. This clinical performance…
The primary objective of this study is to investigate the effect of 26 weeks of supplementation with three different dietary fibres (chicory inulin, resistant dextrin, and seaweed polysaccharide) compared to a placebo (maltodextrin) on microbiota…
Primary Objective:The main goal of the study is to investigate the effects of a chronic increase in the gut microbial metabolite butyrate and hexanoate in the systemic circulation on peripheral insulin sensitivity in individuals with overweight/…
To utilize the therascreen KRAS RGQ PCR Kit (KRAS Kit) as a screening test to identify KRAS G12C mutations in newly diagnosed metastatic NSCLC participants and thereby determine eligibility for enrolment into the Phase 3 clinical study (MK-1084-004…
The primary aim of this study is to assess the efficacy of taVNS in mitigating the acute stress response induced by the Maastricht Acute Stress Task (MAST) among healthy subjects, measured by cortisol levels in saliva samples.Secondary objectives…
Primary objective• Assess the ability of donepezil to reverse biperiden-induced effects on adaptive tracking performance at timepoint 4h Secondary objectives• Evaluate the PK of donepezil and biperiden• Investigation of pro-cholinergic effects of…
In this trial, the researchers want to know how safe AZD8630 is and how well it works to control asthma symptoms when taken with the Saphira inhaler alongside their standard medication. Saphira is a new device that has been designed to deliver…