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The efficacy of Attentional Training on Attentional Bias and Symptoms of Posttraumatic Stress Disorder (PTSD)

Exploring whether ABM is more effective than placebo-ABM in changing attentional bias and alleviating PTSD symptoms in patients (from diverse cultural backgrounds) with PTSD.

A multicenter, randomized, double-blind, placebo-controlled study of the effects of KW-3902 Injectable Emulsion on heart failure signs and symptoms, diuresis, renal function, and clinical outcomes in subjects hospitalized with worsening renal function and heart failure requiring intravenous therapy.

The objectives of this study are to evaluate the effect of KW-3902IV, in addition to standard therapy, on the proportion of worsening heart failure and worsening renal function after initiation of therapy through Day 7 or discharge, whichever occurs…

Effects of Temporary Inhibition of the Renin-Angiotensin System on future blood pressure and hypertensive organ damage in young prehypertensive adults * TIResiAS

To test the hypothesis whether treatment with an ACE inhibitor in young prehypertensive adults reduces blood pressure 2 years after cessation of active treatment and to determine whether this treatment can reduce left ventricular mass and…

Effect of the consumption of a fermented dairy product on constipation in children: a multi-centre randomized controlled trial.

To determine the clinical effect and tolerance of BA in children with functional constipation aged 3-16 years.

The role of adrenal stress hormones in emotional memory: formation, consolidation, and reconsolidation

-Identify the neural correlates of enhanced formation of emotional memory, and parse the role of adrenal stress hormones in this process.-Identify the neural correlates of enhanced consolidation of emotional memory and parse the role of adrenal…

Pharmacological and genetic imaging of executive function deficits

With this study we want to identify the common aetiology and neurobiology of EFD, by employing pharmacological and genetic imaging in three neuropsychiatric disorders. We want to identify an underlying functional and structural model for EFD,…

A methodological investigation to test acute changes in female sexual desire in healthy volunteers and pre- and postmenopausal women diagnosed with hypoactive sexual desire disorders using explicit measures in a controlled laboratory setting and behavioral measures at home, in no-drug as well as placebo-controlled within subjects cross-over drug (a single dose of testosterone gel 50mg [1% in 5g] conditions.

In order to better understand sexual desire (e.g., fluctuations in desire, level of desire to distinct sexual stimuli varying in intensity, subtypes of desire disorder) it is important to examine methods for rapid detection of desire changes.…

German Trial of Acyclovir and Corticosteroids in Herpes-simplex-virus-encephalitis (HSVE); a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial.

GACHE aims to evaluate the effect on morbidity and mortality of early adjuvantcorticosteroids (dexamethasone) in the treatment of adult patients with HSVE. The major motivation for this trial is the extremely unsatisfactory outcome of patients…

'The effects of Omega-3 Fatty Acids Dietary Supplements (Fish Oil) on Impulsivity in Patients with a Personality Disorder'

The primary research question of this study is:*What is the effect of omega-3 fatty acids dietary supplementation compared to placebo in the treatment of impulsivity in patients with a personality disorder?*The secondary research question of this…

Assessment of Perinatal Outcome after Sustained Tocolysis in Early Labour (APOSTEL II)

To evaluate the effectiveness of tocolytic maintenance therapy for postponing delivery after initial 48-hour tocolytic therapy in women with threatened preterm birth from 24-32 weeks gestational age.

Efficacy of a mamma fieldblock in oncological breast surgery in reducing postoperative nausea and pain.

Reducing postoperative pain and nausea improves patient satisfaction.

Systemic effects in patients with COPD; training or treatment

To study the possible relation between systemic inflammation and oxidative stress and muscle breakdown using pharmacological interventions.

A randomised placebo-controlled trial in the management of ostheoarthritis of the temporomandibular joint for arthrocentesis with additional dexamethasone versus arthrocentesis alone.

This study examines if there are therapeutic benefits over injecting dexamethason into the temporomandibular joint after arthrocentesis with patients with ostheoarthritis.

A randomised, double-blind, placebo-controlled, multicentre, Phase II dose-finding study of atacicept given subcutaneously in subjects with rheumatoid arthritis and inadequate response to TNFa antagonist therapy

The goal of this research trial is to evaluate the efficacy, tolerability and safety of atacicept in patients with active rheumatoid arthritis who have an inadequate response to other treatment(s). In addition, the study will also measure the…

Study of the Safety and Efficacy of Anercortave Acetate for Treatment of Steroid Induced IOP Elevation

The primary objective of the study is to evaluate the safety and efficacy of Anecortave Acetate Depot (3, 15 or 30 mg) when administered by AJD for treatment of elevated IOP following intravitreal steroid therapy.

The influence of stress hormones on the reconsolidation of emotional memories

The present study will examine whether administration of a beta blocker (propranolol) and cortisol (hydrocortisone) to a healthy male population during retrieval of emotional memories in healthy subjects will lead to long term changes in these…

The effect of rosiglitazone on ischemia-reperfusion-injury using annexin A5 scintigraphy.
A double blind placebo- controlled cross-over study in subjects with the metabolic syndrome

To estimate the effect of rosiglitazone compared to placebo on ischemia-reperfusion injury as assessed by annexin A5 scintigraphy in the human forearm in subjects with the metabolic syndrome.

A Multicenter, Double-blind, Randomized, Parallel, Placebo-controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of 2 Oral Doses, 25 mg Twice Daily and 100 mg Twice Daily, of PG 760564 in Adult Patients with Rheumatoid Arthritis Receiving Methotrexate

The objectives of this study are as follows:Primary Efficacy Objective:• To assess the effect of PG-760564 on the proportion of patients meeting the American College of Rheumatology 20 response criteria (ACR 20) at 12 weeks;11Secondary Efficacy…

Sportsmen, TEP repair versus Endoscopy trial

The objective of this study is to demonstrate the effectivity of TEP repair in the treatment of a sportman's hernia.

A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous AMG 108 in Subjects with Rheumatoid Arthritis

The primary objective for this study is to determine whether AMG 108 at a monthly dose of 250 mg SC or less in combination with MTX demonstrates a higher frequency in clinical response (ACR20) than that observed with placebo (MTX alone) in RA…