Search for a trial

The effect of the α7nACh receptor agonist GTS-21 on inflammation and end-organ dysfunction during human endotoxemia

to study the effect of pre-treatment with the specific a7nAChR agonist GTS-21 on cytokine production and the effects on the subsequent subclinical organ dysfunction in the human endotoxemia model. to measure the effect of LPS administration in the…

Study of the efficacy of calcium and phosphate containing fluoride paste and a placebo paste to promote remineralisation of caries developed during orthodontic treatment with fixed appliances.

Our aim is to find methods to effectively remineralize caries lesions that have developed during orthodontic treatment. A secondary aim is to study the effect of fixed orthodontic appliances on the plaque ecology in relation to caries development in…

Effectiveness of Extracorporeal Shockwave Therapy in Jumping Athletes with Patellar Tendinopathy

Aim of this study is to determine the effectiveness of ESWT on pain, symptoms and function, in athletes with patellar tendinopathy (in an early stage of the disease) who are still able to train and compete.

A phase II, randomized, double-blind, placebo-controlled trial investigating the efficacy and safety of Org 3236 tablets in men with Lower Urinary Tract Symptoms (LUTS) suggestive of Benign Prostatic Hyperplasia (BPH)

The objectives are to evaluate:- The effect of Org 3236 on prostate volume compared to placebo;- The effect of Org 3236 on LUTS compared to placebo;- The effect of Org 3236 on urinary flow and postvoid residual volume compared toplacebo;- The effect…

A double-blind, randomized, placebo controlled, single oral dose, two way cross-over trial to investigate the effects of an orally administered 5-HTP challenge test on hypothalamic fMRS activation in healthy male volunteers.

Primary Objectives:- To investigate the effects of a single dose (plasma concentration) 5-HTP challenge test (5-HTP200mg/CBD100+50mg/granisetron2mg) on hypothalamic fMRS activation patterns in healthy male volunteers.Secondary Objectives:- To assess…

Protocol of Placebo controlled double blind study for the treatment of psoriasis with blue light

The target of this study is to determine if blue light of 420 nm is effective against psoriasis

A Phase 4 Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Centre Study of Colesevelam as Add-on Therapy in Patients with Familial Hypercholesterolaemia.

This study is being conducted in patients with familial hypercholesterolaemia (FH) to:1. Assess the efficacy of colesevelam added to a maximal tolerated and stable regimen of statin and ezetimibe in further decreasing the low-density lipoprotein (…

Placebo controlled trial to evaluate the effect on pain and function of six months treatment doxycycline in established knee osteoarthritis with an open extension up to two years

To asses the short and long term effect on pain and function and the safety of doxycycline in patients with mild to severe pain due to established knee OA.

Een gerandomiseerde placebo gecontroleerde studie naar de toegevoegde waarde van D-cycloserine aan exposure therapie bij pati??nten met een poststraumatische stress stoornis

The present study is aimed at testing the effects of D-cycloserine in addition to exposure treatment sessions in PTSD patients, in a randomized double blind placebo controlled study.

Double blind, placebo controlled study Tacrolimus versus Emmolient in localized scleroderma

The primary objective of this study is to assess whether tacrolimus is effective for the treatment of morphea.

A PROSPECTIVE RANDOMIZED STUDY ON THE EFFICACY AND SAFETY OF THE PROPHYLACTIC USE OF RITUXIMAB, ADDED TO STANDARD IMMUNOSUPPRESSIVE TREATMENT IN COMPARISON WITH STANDARD IMMUNOSUPPRESSIVE TREATMENT ALONE IN RENAL TRANSPLANTATION

To determine the effect of rituximab, when added to standard immunsuppressive therapy, on the incidence and severity of biopsy-confirmed acute rejection within the first six months after transplantation.

A randomised, double-blind, placebo controlled, multicentre,
exploratory, pilot, phase II trial of 150 mg
atacicept given subcutaneously in combination with
rituximab in subjects with rheumatoid arthritis.

Primary objective:* To assess the safety and tolerability of combined treatment with atacicept and rituximab insubjects with active rheumatoid arthritis receiving re-treatment with rituximab.Secondary objectives:* To evaluate the effect of combined…

Challenge study: The efficacy of fish oil supplementation on cognitive performance in MCI patients and the influence of the APOE-epsilon4 allele.

To study the short term effects of a pharmacological dose of fish oil on cognitive performance and on cerebral blood flow. Furthermore, we want to investigate whether carriers of the APOE*4 allele respond differently to fish oil treatment compared…

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Patients with Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy

Primary objective:To compare the clinical benifit of abiraterone acetate plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer (CRPC) who have failed one or two chemotherapy regimens, one of…

Diurnal and segmental variation in glucose sensing: effects on homeostasis, satiety and energy intake in healthy volunteers

The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…

Study on the effect of pain medication on functional capacity and self reported disability in patients with chronic low back pain;
a triple blinded RCT

This study aims to investigate the effect of analgetics on a functional capacity evaluation (FCE) and self reported disability in patients with CLBP.

Evaluation of FGF-23 suppressibility by Calcitonin in Healthy Men- pilot study

In this studie we wish to examine the FGF-23 suppressive effects of calcitonin in healthy men.

A blinded, randomized, placebo-controlled trial in genotype 1 hepatitis C-infected subjects to evaluate the efficacy, safety, tolerability and pharmacokinetics of repeated doses of TMC435350, with or without peginterferon alpha-2a and ribavirin.

The primary objectives of this trial are the following:- to determine the dose dependency of the antiviral effect of TMC435350 during 1 week ofmonotherapy in treatment-naïve HCV-infected subjects;- to determine the dose dependency of the antiviral…

A single-center, randomized, placebo-controlled, two-way crossover study to investigate the drug-drug interaction on the pharmacokinetics and pharmacodynamics of ACT-078573 and single-dose desipramine in healthy male subjects

Evaluation of the pharmacodynamic and pharmacokinetic effects of multiple doses of ACT-078573 on the pharmacokinetics of a single dose of desipramine

A double-blind, randomized, placebo-controlled, cross-over, single center, pharmacodynamic trial to collect data for quantitative modeling of HPA axis modulation with desmopressin and CRH in healthy volunteers

Primary objectives:1) Describe the PD effects on plasma ACTH and serum cortisol upon 100 µg hCRH injection with or without a preceding injection of 10 µg dDAVP 2 hours earlier and study the PK-PD relationship (*Block B*). In particular, the outcome…