63 results
The main aim of this study is to find out if the continuation of bevacizumab, in addition to standard 2nd & 3rd -line treatment, can help patients with NSCLC that has progressed to live longer. The study also aims to find out if continued…
The aim of this study is to validate known, and identify novel allelic variants which may play a role in the risk of cisplatin-induced ototoxicity in a substantial international cohort of children diagnosed with cancer.
Primary objective: To compare the severe (acute and late) toxicity (Grade 3-5), as assessed by CTCAE Version 4, caused by cetuximab and RT to that caused by cisplatin and RT in patients with HPV+OPSCC.Secondary objectives:- Compare overall number of…
The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…
Primary Objectives* Phase 1b lead-in: To assess safety and tolerability of a single dose level of avelumab in combination withincreasing dose levels of other immune modulators in combination with a single doselevel of avelumab in patients with…
Primary objective is to demonstrate a 25% reduction of the active irinotecan metabolite, SN38, in healthy liver tissue in patients with mCRC or other solid tumors as a result of preceding dietary restriction five days in advance. Secondary…
The project primarily aims to study short (3 and 6 months) and long term (12 months) health related effects of the 'Kanker Nazorg Wijzer' on survivors' psychosocial distress and quality of life (QoL). Furthermore, process aspects of…
The primary objective of this study is to determine the impact of a diagnosis and type of treatment of cancer, ageing and their interaction on wellbeing of older cancer patients. Furthermore, we aim to determine the different psychosocial…
The objective of the study is to determine the clinical relevance of sparing the lymfdrainage of the upper extremitiy by using the ARM-procedure in patients with breast cancer. The purpose of the continuation of the feasibility study is to create a…
To observe a decrease in number of definite and/or suspected pneumonia after prophylactic treatment with antibiotics during CRT in patients with LAHNC.To observe a decrease in the number of admissions in the hospital To observe a decrease in the…
In this study, we aim to improve recognition of delirium in a palliative care population with advancedcancer and we aim to provide evidence for optimal treatment of delirium through adequate dosing ofpreferred neuroleptic.Primary objectives:1) To…
The objective of the study is to identify potential platelet-derived angiogenic and angiostatic tumorbiomarkers. Initially platelet proteomics will be used to detect potential tumormarkers. Subsequently, these potential tumorbiomarkers will be…
The aim of this prospective study is the prevention of progression of premalignant lesions to invasive head and neck cancer by modifying the out-patient follow up and patient management.
The proposed phase II study will test the hypothesis that preventive swallowing exercises (PSE) during treatment will reduce the incidence of swallowing dysfunction among patients with HNSCC treated with curatively intended (CH)-RT using SWIMRT. As…
Primary objectives:(1) Prevent progression of precursor lesions of the head and neck mucosa by treating selected lesions at risk for malignant outgrowth(2) Demonstrate that the detection of chromosomal instability (CIN) is indeed a powerful tool to…
Primary objective: to obtain an comparison of the diagnostic result after an ultrasound assisted fine needle aspiration cytology (FNAC) of the thyroidal gland by use of a smaller diameter (25G) and / or a special coating.
The primary objective of this study is to evaluate the hypothesis that cixutumumab given in combination with cisplatin and pemetrexed is superior to cisplatin and pemetrexed as first-line therapy for patients with advanced nonsquamous non-small cell…
To determine the relative bioavailability of ciprofloxacin oral suspension versus oral tablets in pediatric cancer patients, and to determine the absolute bioavailability of tablets and suspension utilizing the 100% bioavailability of intravenous…
To determine the maximum tolerated dose (MTD), dose limiting toxicities (DLT), and optimal dose of docetaxel that can safely be administered to patients with cancer in a weekly schedule. amendment 1The objective of the first amendment is to…
To determine the improvement in symptoms of constipation in subjects receiving treatment with oxycodone/naloxone prolonged release tablets (OXN) compared to subjects receiving oxycodone prolonged release tablets (OXY) based on the Bowel Function…