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Utility of BOLD MRI as diagnostic tool in renal artery stenosis in patients with hypertension and chronic kidney disease

Is the BOLD MRI able to show the difference in the level of oxygenation as a mesurement of ischemia between a in a healthy kidney (<30% renal artery stenosis) and a kidney with more than 70% artery stenosis?

SYMPATHY: Renal sympathetic denervation as a new treatment for therapy resistant hypertension.

The primary objective is to assess whether RD added to usual care compared to usual care alone reduces BP (24-h or average day-time SBP as determined with the use of ambulatory BP monitoring (ABPM)) in subjects with an average mean day-time SBP of…

A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibitor in de novo renal transplantation- Advancing renal TRANSplant eFficacy and safety Outcomes with an eveRolimus-based regiMen (TRANSFORM)

Primary: to evaluate the effect of everolimus with reduced exposure CNI versus MPA with standard exposure CNI on the binary composite of treated biopsy-proven acute rejection (tBPAR) or eGFR < 50mL/min/1.73m2 at Month 12 post-transplantation.…

A Phase 3, Randomized, Open-Label, Active-Controlled Study to Evaluate the Efficacy and Safety of roxadustat in the Treatment of Anemia in Chronic Kidney Disease Patients Not on Dialysis

The primary objective of this study is to evaluate the efficacy of roxadustat compared todarbepoetin alfa in the treatment of anemia in non-dialysis dependent Chronic Kidney Disease (NDD-CKD)subjects.The secondary objectives of this study are to:*…

Cardiovascular (CV) risk prediction and CV biomarkers in renal transplant recipients treated with belatacept compared to calcineurin inhibitors (CNI).;Open randomized 12 month study.

The goal of this study is to prove whether kidney transplant recipients can reduce their risk of cardiovascular disease bij converting to Nulojix.

A multicenter, randomized, double-blind, double-dummy, parallel-group, active-controlled study to evaluate the efficacy and safety of finerenone compared to eplerenone on morbidity and mortality in patients with chronic heart failure and reduced ejection fraction after recent heart failure decompensation and additional risk factors, either type 2 diabetes mellitus or chronic kidney disease or both.

Demonstrate the superiority of finerenone to eplerenone in delaying time to first occurrence of the compositeendpoint, defined as cardiovascular (CV) death or hospitalization for heart failure (HF), in patients withCHF (NYHA class II-IV) and reduced…

Neurotoxic adverse effects of morphine and oxycodone in continuous subcutaneous infusion for treatment of pain in terminal patients with diminished renal function: a Randomized Controlled Trial.

The primary objective of this study is to compare the prevalence of delirium between oxycodone and morphine, administered by CSCI, for the treatment of pain in dying patients with a diminished renal function.The secondary objective is to compare the…

Anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with renal impairment using a dosage guideline of the Dutch Federation of Nephrology

The primary objective of this study is to determine the anti-Xa activity after a reduced therapeutic dose of nadroparin in patients with an eGFR < 60 ml/min in comparison with the anti-Xa activity after a standard therapeutic dose of…

Group rehabilitation for renal patients

The purpose of GRN-study is: 1. to determine the long-term effectiveness of a 12 weeks lasting physical exercise training program. 2. to determine the costeffectiveness of the 12 weeks lasting physical exercise training program. In aim of the GRN-…

Renal concentrating capacity and plasma AVP/copeptin levels during a water deprivation test in ADPKD patients versus healthy subjects and patients with chronic kidney disease.

Primary Objective: • To compare urinary concentrating capacity in ADPKD patients with healthy subjects and patient with IgA- or membranous glumerulopathy.Secondary Objectives:• To compare urinary concentrating capacity in ADPKD patients with an eGFR…

Long-term follow-up after live kidney donation; A matched, controlled study on renal function and quality of life.

To assess the long-term consequences of live kidney donation, regarding kidney function, survival, hypertension, diabetes, systolic and diastolic blood pressure, mental state and quality of life.

Effects of dietary sodium restriction on blood pressure in renal transplant recipients: an intervention study

Primary Objective: •To investigate the effect of dietary sodium restriction on blood pressure and use of antihypertensive medication in renal transplant recipients.Secondary Objective(s): •To investigate the effect of dietary sodium restriction on…

The Thrombin generation Test in Kidney disease Study

The overall aim of this study is to evaluate the use of the thrombin generation test in patients with CKD, including haemodialysis-dependent patients.

Advanced MRI in renal tumours

To evaluate the diagnostic performance of diffusion weighted MR imaging (MRI) techniques by using apparent diffusion coefficient (ADC) maps and Diffusion Tensor Imaging (DTI) on 3 tesla MRI in assessing the nature of renal masses.

A randomized controlled trial comparing deep versus moderate neuromuscular block - in low pressure pneumoperitoneum - to optimize the surgical conditions during laparoscopic donor nephrectomy

To investigate whether the use of deep neuromuscular block improves surgical conditions in low pressure laparoscopic donor nephrectomy

The clinical effect of mTOR inhibition on lipid metabolism in renal transplant recipients

to study the effect of everolimus (vs. mycophenolate) on dyslipidemia, ectopic fat accumulation, and cardiovascular function against a common calcineurin inhibitor (CNI) background.

Creation of buttonhole cannulation tracks: conventional vs supercath

Compare succesfull creation and usage of the buttonhole track for hemodialyses, created by either the conventional way or with the supercath

Response to angiotensin II in formerly preeclamptic women. RETAP study.

Primary Objective: Primary endpoints will be renal (ERPF, GFR and FF) response to angiotensin II after low and high sodium diet in formerly preeclamptic patients compared to healthy controls. Secondary Objectives: Secondary endpoint will be systemic…

Effect of N-acetylcysteine on hydrogen sulfide in chronic kidney disease

Primary Objective: Our primary objective is to investigate the effect of NAC on H2S levels in plasma in different patient groups, i.e. healthy volunteers, CKD patients, and dialysis patients. We hypothesize that there is an increase in H2S levels…

Pilot study into the endothelial function in paediatric renal transplant recipients by means of peripheral arterial tonometry

Ascertain feasibility, study burden, between-subject and within-subject variability of automated RH-PAT measurements in paediatric renal transplant recipients. Comparison of adipokines and inflammatory profiles in renal transplant recipients and…