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Fixed versus variable dosing strategy of prothrombin complex concentrate for bleeding complications of vitamin K antagonists

To test whether the clinical outcome of lower fixed dose of PCC is superior to higher variable dose of PCC, for VKA related bleeding in a randomized setting. Secondary objectives include the comparison of INR after administration of PCC, time to…

Leukocyte dynamics during immune reconstitution after stem-cell transplantation: in vivo labelling of dividing leukocytes using deuterated water

In this study we aim to gain more insights into immune reconstitution of various leukocyte populations after SCT. By application of heavy water labeling we investigate if and how the production- and death rate of leukocytes changes after an SCT.

Effects of DDAVP (1-deamino-8-D arginine vasopressin) infusion on parameters of hemostasis in patients with liver cirrhosis

This study aims to collect biochemical evidence for the pro-hemostatic capacity of DDAVP in patients with cirrhosis, in order to proceed towards a more rational clinical use of this drug.

Gamma Probe and Ultrasound Guided Fine Needle Aspiration Cytology of the Sentinel Node Trial

To study the sensitivity of the combined gamma probe and US guided FNA compared to the gold standard histology of the surgically removed SNB. Secondary aims 1) to study the identification rate of this technique 2) to study possible differences in…

Reducing pain and discomfort during and after bone marrow aspiration

The main objective of this study is to investigate which premedication scheme reduces best the pain during and after a BMAB and reduces best the fear for a possible next BMAB. Other objectives are the influence of the different medication schemes on…

Targeted Abdominal Lymph nodE dissections randomized for surgical NavigaTion (TALENT)

To evaluate if navigation assistance results in more successful localization and removal of extra-regional abdominal lymph nodes compared to standard surgery. Extra regional lymph nodes are defined as suspect target lymph nodes outside the standard…

A Randomized Controlled Trial on Prophylactic Platelet Transfusion Prior to Central Venous Catheter Placement in Patients with Thrombocytopenia

Our objective is to determine in a controlled study whether not correcting thrombocytopenia prior to CVC placement is non-inferior compared to correcting. In the Netherlands annually 17.700 units PC are possibly unnecessary transfused, for the…

Deep inferior epigastric perforator flap breast reconstruction with or without inguinal lymph node transplant for treatment of breast cancer related arm lymphedema:
A multicenter randomized controlled trial

The aim of this study is to evaluate investigate whether BCRL will improve in patients with BCRL undergoing DIEP-flap BR combined with an inguinal lymph node transplant have statistically significant improvement of their BCRL (primary objective),…

MR lymphography and magnetic sentinel lymph node biopsy in melanoma patients measured with DiffMag

In this pilot study we want to evaluate the clinical use of the DiffMag handheld probe, and compare the detection and usability of the DiffMag with the radioactive detection and the detection of the SentiMag for furthur optimazation of DiffMag…

Sentinel Lymph Node Procedure in Testicular Germ Cell Tumour

Assessment of accuracy of sentinel node biopsy, defined as the false negative rate.

The LYMPH Trial - Surgical versus Conservative Complex Physical Decongestion Therapy for Chronic Breast Cancer-Related Lymphedema: A Pragmatic, Randomized, Multicenter Superiority Trial

Primary Objective:The primary objective of this trial is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, upper limb, questionnaire) 15 months after randomization (and therefore about one year after surgery)…