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PRognostic hEModynamIc profiling in the acUte ill eMergency department patient: PREMIUM registry

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HEalthy LIfe in an Urban Setting (HELIUS): a prospective cohort study on health and health care utillization among different ethnic groups in Amsterdam

The general objective of HELIUS is to describe (trends in) patterns of chronic conditions across six ethnic groups over time, and to unravel the causes of (the unequal burden) of chronic diseases across ethnic groups, with an emphasis on…

Testing for sepsis in primary care: diagnostic and prognostic study investigating the potential benefits of point-of-care testing

The objective of the study is to improve the detection of sepsis in primary care by developing a clinical decision rule for GPs, consisting of the most relevant clinical features and point-of-care (POC) measurements of biomarkers. This decision rule…

Researching the Effects of Sepsis on Quality Of life, Vitality, Epigenome and gene expression during RecoverY from sepsis (REQOVERY)

To study the long-term changes in DNA methylation and gene expression in sepsis survivors and their association with long-term morbidity and mortality after sepsis.

Identifying the underlying mechanisms and consequences of the loss of nasal T cells in vital and frail older individuals

Primary Objective: To compare nasal CD8+ T cell frequency between young adults and frail older adults.Secondary Objective(s): 1. In depth profiling of T cells in nose and blood of young adults and older adults with and without frailty.2. Assess the…

Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP)

This study has been transitioned to CTIS with ID 2023-507889-89-00 check the CTIS register for the current data. REMAP-CAP: The goal of the study is to investigate the best treatment regime for pneumonia patients. For non-pandemic pneumonia (…

Preterm Immune system development and response to Immunization

Primary objective is to study the antibody immune response to routine vaccinations in very preterm infants (GA<32 weeks). Secondary aim is to study the immune system more extensively using flow cytometry, ELISA and single cell transcriptomics…

Procalcitonin-guided treatment regarding antibiotic use for acute COPD exacerbations: a prospective randomised controlled trial

Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…

The effect of postoperative glucose control with a basal bolus versus a sliding scale insulin regimen on the incidence of surgical site infections in people with type 2 diabetes mellitus: A multicentre, matched-pair, cluster-randomised controlled trial

The aim is to reduce SSI in PWT2D by implementing a proactive basal-bolus insulin regimen, compared to a widely used reactive sliding scale regimen. It is hypothesised that a proactive basal-bolus insulin regimen targeting glucose levels of 3.9-10…

Protecting against Respiratory tract Infections through human Milk Analysis.

Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…

Evolution of mitochondrial dysfunction and hypermetabolic inflammatory status in septic Intensive Care Unit patients

The main objective is to investigate how mitochondrial function progresses over time in septic ICU patients. The secondary objective of the study is (a) to investigate how mitochondrial dynamics progress over time and how this is associated with…

International GBS Outcome Study
A prospective INC study on clinical and biological predictors of disease course en outcome in GBS

The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…

Vaccinations in the Immunocompromised population: paramount and paradox.

The objective of this study is to determine the immune response after hepatitis A and pneumococcal vaccination in different groups of ICPs. The overarching aim of the study is to improve vaccine regimens and to optimize guideline recommendations…

Technical validation of transport and temperature stability at room temperature of presepsin measured with Elecsys® Presepsin.

The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…