21 results
We will investigate the effect of the combination of moderate physical activity and a standard meal on the onset of low grade intestinal ischemia. Will will use the serological biomarker I-FABP to determine the occurrence of low grade intestinal…
* To determine the minimum effective dose of 5-aminolevulinic acid (Gliolan) for adequate MitoPO2 measurements during upper endoscopy.
To determine the difference in EGG patterns in a fasting state and after a test meal between healthy controls and patients suffering from splanchnic ischemia (both single and multiple vessel stenosis). We hypothesize that patients with splanchnic…
- To determine the difference in baseline mucosal oxygen saturation measurements and after luminal feeding between patients diagnosed with CGI and healthy subjects. - To determine the difference in baseline mucosal oxygen saturation measurements…
Primary Objective: for each new catheter design: in-vitro establishment of time-dependent correction factors for saline-use and establish the accuracy of CO2 measurement with the capnograph. In-vivo: establish the feasibility and measurement errors…
To evaluate the prevalence of gastrointestinal ischemia in patients with acute and chronic non-cirrhotic, non-malignant PVT.
Specific research objectives:Investigate the effect of orally administered citrulline at:- Circulation of gastrointestinal (GI) system- The occurrence of GI damage, liver and kidneys- The GIpermeability - Production of amino acids- Endothelial…
Evaluation of the diagnostic value of stomach and small bowel mucosal oxygen saturation measurements in patients suspected for chronic gastrointestinal ischemia.Determination of normal mucosal oxygen saturation values in patients without chronic…
First goal is the evaluation of plasma and urinary FABP levels as useful indicators for diagnosis of intestinal ischemia. Second goal is to study whether combinations of proteins from the family of FABPs provide insight in the localization of…
To evaluate the use of the early serum markers I-FABP, D-dimer, DAO and alpha-GSTin predicting CGI one by one.To evaluate the use of Citrulline to determine the bowel function in patients with CGI.
The objective is that 6 standard ligation of hemorrhoidal arteries is as effective as doppler guided.
To determine the feasibility of the MitoPO2 measurements during upper endoscopy.
We aim to validate a panel of plasma biomarkers and investigate volatile biomarkers that potentially allow early and accurate identification of acute intestinal ischemia in patients. Second, we aim to identify a volatile organic compound (VOC)…
This study aims to investigate whether the intraoperative use of indocyanine green fluorescence angiography (ICG-FA) is feasible and safe in neonates. Feasibility is therein defined as practically possible use of ICG-FA, resulting in clear and…
The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.
To determine the difference in baseline MR flow measurements and post-prandial MR flow measurements between patients diagnosed with CGI and patients not diagnosed with CGI. To gather information on the potential of endoscopic mitochondrial oxygen…
Facilitating diagnosis of chronic mesenteric ischemia (CMI) using 1) the mesenteric artery calcium score (MACS) and 2) mucosal ischemia detection by butyrate breath testing
To compare the outcome of revascularisation the gastrointestinal arteries using covered stents compared to bare-metal stents in patients with CGI.
To assess procedural hemodynamic indices of paravalvular leakage and to relate these to cardiac MRI at 1 month and clinical follow-up over 5 years.To diagnose angiodysplasia en determine the effect of TAVI on these angiodysplastic lesions.
Intra-arterial pressure measurements are currently the most promising tool to guide clinical decision making in patients with suspected CMI. Implementation of pressure measurements could result in major improvements in quality of life by tailoring…