40 results
The main objective of the trial is to show that ABVD-based response-adapted therapy for advanced-stage Hodgkin lymphoma, with treatment intensification (BEACOPP) in case of a positive FDG-PET after one cycle of ABVD, has non-inferior efficacy…
The objective of the study is to diminish the amount of chemotherapy and/ or radiotherapy for children with Hodgkin lymphoma who are likely to receive too much treatment with current treatment protocols.
Primary Objective* To characterize the pharmacokinetics (PK) of different dosing regimens of avelumab and its relation to target occupancy (TO) in peripheral blood of patients with classical Hodgkin*s Lymphoma (cHL).Secondary Objectives* To evaluate…
To determine appropriate dosing regimens for use in future clinical trials of GS 9820 in subjects with lymphoid malignancies.
(1) To evaluate the effectiveness of an individualized exercise program in comparison to standard care with respect to fatigue, physical fitness and health-related quality of life in patients with hematologic malignancies who have undergone HDC and…
Primary objectives:1: To determine whether CT- coronary angiography by MSCT as a screening method of HL survivors treated with mediastinal irradiation accurately identifies asymptomatic significant coronary artery disease. 2: To establish the…
The aim of this study is to identify risk factors for various CVDs, i.e. to quantify separate and joint effects of radiation dose to the heart, anthracycline dose, other CT, life style factors, established CVD risk factors and genetic susceptibility…
1º Is there a significant difference of more than 10% in the pharmacokinetic parameter AUC of the investigated antineoplastic drugs (as a surrogate parameter for the efficacy) in the presence and absence of NNRTIs and/or PIs?2º Are there clinically…
Primary• To assess the safety profile and determine the pediatric maximum tolerated dose and/or recommended phase 2 dose of brentuximab vedotin• To assess the pharmacokinetics of brentuximab vedotin• To determine the overall response rate (complete…
In preparation of a larger RCT we aim to conduct a pilot study which investigates the feasibility of the described physical exercise program and its effects. Purpose of this study is to develop this exercise program, to test the implementation and…
To evaluate whether chemotherapy alone is as effective -but less toxic-, as combined modality treatment in terms of progression-free survival (PFS), in patients with stages I/II Hodgkin*s lymphoma who are FDG-PET scan negative after two cycles of…
The aim of this project is a prospective study of blood samples of HL patients to determine the value sensitivity and specificity of increase TARC an MDC serum levels for the early detection of a relapse.
In the third follow-up we will include both factory A and B. The mayor strength is the increase in power by addition of approximately 15 years of follow-up. We will investigate the association between exposure and mortality, cancer mortality and…
The main objectives are :Cross-sectional:1. To investigate the extent of atherosclerotic disease of the carotid artery defined as: (a) the intima-media thickness (IMT) (b) the elasticity (c) the degree of stenosis2. To define the degree of…
The objective of this study is to measure quality of life, health care use and morbidity (like fatigue, anxiety and depression) of patients diagnosed at least 2 years ago. These variables will be compared between the different treatment modalities…
To respectively evaluate the fertility parameters before and after treatment for pediatric HL in the Netherlands according to the COG protocols for low risk, intermediate risk and high risk, to test the hypothesis that these protocols will not harm…
The aims of this study are to compare the diagnostic performance of whole-body MRI (including DWIBS) to FDG-PET/CT and/or CT for the initial staging, early response assessment and restaging after completion of therapy in children with Hodgkin*s…
Primary objectives:(1) To determine the safety and tolerability of pembrolizumab. (2) To evaluate the Overall Response Rate (ORR) of pembrolizumab by independent central review according to the International Working Group (IWG) response criteria (…
PrimaryPhase 1-To characterize the safety and tolerability of isatuximab in combination with cemiplimab in participants with relapsed and refractory cHL, DLBCL or PTCL, and to confirm the recommended Phase 2 dose (RP2D).Phase 2- Cohort A1 (anti-…
Main objective:1. To estimate the Overall Response Rate (ORR) and the clinical benefit rate in selected cohorts of patients with hematologic malignancies,separately for each cohort2. To evaluate the safety of the selected dose regimes in an expanded…