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Determination whether the lack of functional AQP2 in kidneys of patients suffering from nephrogenic diabetes insipidus induces cyst formation

Does the lack of the Aquaporin-2 water channel cause cyst formation in patients suffering from nephrogenic diabetes insipidus?

Single Blind Randomized Phase III Trial to Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer

- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…

Outcome study on gender identity, sexual functioning and psychological well being in patients with a disorder of sexual differentiation

In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well

The effect of position (sit/stand up vs supine position) on urge sensation in volunteers and in patients with overactive bladder syndrome

The primary objective of this experiment is to describe via an observational study the relation between conditions of sitting/standing up versus laying down in terms of bladder sensation in both volunteers and patients with OAB. We also want to…

TRanslabial 3D-Ultrasonography for DIagnosing Levator defects

Objective:Primary aim of the study is estimating the diagnostic accuracy of translabial 3D ultrasonography of thepelvic floor as compared to MR imaging, the reference standard, for diagnosing levator defects inwomen with POP. Our secondary aim is…

T cell homeostasis after ATG induced lymphocytopenia in renal transplant patients; studied through in vivo 2H2O labeling

To get more insight into the T cell homeostasis in lymfocytopenic, ATG treated patients and normocytopenic patients treated with standard maintenance immunosuppressive drug therapy.

Intracytoplasmatic Sperm Injection using testicular spermatozoa in men with azoospermia; an observational study with follow-up of the offspring.

To evaluate the efficacy of TESE and to describe the risks of the TESE procedure for the men with a four year follow-up of their offspring.

Application of PET-MR- a diagnostic accuracy study of combined dwMRI and 18F-Choline PET-CT for baseline staging of prostate cancer validated by extended laparoscopic lymph node dissection.

To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)

Validation and standardization of the measurement of pelvic floor dysfunction with the MAPLE-probe

A. Determine the placement of the Maple-probe in relation to the anatomy of the pelvic floor musculature.B. Determine the normal rest tone of the pelvic floor musculatureC. Determine the normal activity of the pelvic floor musculatureD. Determine…

Long term functional outcome, quality of life, and genetic factors in patients with a cloacal malformation

The primary objective to our study is assessing functional outcome, quality of life, and genetic mutations in patients with a cloacal malformation. Functional outcome:- Colorectal functiono Objective: assessing colorectal function through the use of…

THE KIMONO-study - on the development of renal injury in children with a solitary functioning kidney.

THE KIMONO-STUDY is designed to study the consequences of having an SFK from childhood. Furthermore, a tailor made risk profil will be designed for children with an SFK, based on individual risk factor (for example co-morbidity, genetic aberrations…

Testicular volume after prepubertal orchidopexie of the acquired non scrotal testis

In this study we aim to investigate the long-term results of the prepuberal orchidopexie for the acquired undescended testis. The volume and location of the testis are primary outcome parameters that display the result. This information will…

A randomised controlled trail comparing the TVT-O® with the Ajust® as primary surgical treatment of female stress urinary incontinence.

Objective: Primary Objective: to compare the immediate and postoperative pain (up to 6 weeks) between the Ajust® and TVT-O® proceduresSecondary Objective(s): 1. Objective cure of the SUI at 6 and 12 months follow up2. Subjective cure and improvement…

153Sm-EDTMP versus docetaxel for multiple painful osseous metastases in prostate cancer

The sequential application of chemotherapy and radionuclide treatment in patients with symptomatic osseous metastasized prostate cancer. Patients with more than one painful osseous metastasis will be randomized between 153Sm-EDTMP or docetaxel 3…

Clinical and histologic effect of transrectal intraprostatic injections with botulinum toxin in patients with lower urinary tract symptoms caused by benign prostatic hyperplasia.

To determine the effect on lower urinary tract symptoms and to determine urodynamic and histologic changes after intraprostatic botulinum toxin type A injection.

Evaluation of the pelvic floor patients with Pelvic Organ Prolaps (POP) and controls, using dynamic MRI and Diffusion Tensor Imaging (DTI).

In this study we aim to evaluate pelvic floor structures in both POP patients and controls with the use of different anatomical landmarks and reference lines in non-invasive dynamic MRI. Additionally we propose to evaluate the feasibility of DTI in…

Sexuality of hospital patients and their partners: a pilot study

This pilot study aims to investigate sexual wellbeing, sexual functioning and sexual health care need within four groups of patients with major illness (COPD patients, gynaecological patients, pelvic care patients, and patients with depressive…

Pilotstudy to characterise prostate tissue using dynamic contrast enhanced (DCE-) MRI in patients with localised prostate cancer.

This is a pilotstudy after characterising prostate tissue by using DCE-MRI in patients with a localised prostate cancer.The relation between DCE-MRI and vasculature and oxygenation will be investigated as a preparation for further studies.

The multiparameter MLC-CFSE test to predict T cell-allo-immune reactivity in renal transplant recipients.

To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.

Pilot study for the project:
A randomized clinical trial of urinary incontinence in older women: cost-effectiveness of protocolized assessment and evidence based treatment

The objective of the pilot study is to get information on the recruitment of patients, the filling in of the questionnaires, the micturition diary, the course of and information from the interview and about the logistics of the urogynaecological…