45 results
The main aim is to investigate clinical effects of different implementation methods of online supported self-management for COPD patients in primary care. Secondary objectives include effects on well-being, health care use and actual use of the…
The generic objective of the study is to explore associations between exposure to livestock farms and potential health effects. This study will focus on 1) respiratory health effects, 2) Livestock associated infections (zoonoses), 3) Carriage of…
Primary objective of the study is to record TIP inhalations on video at home to study the association between inhalation manoeuver and cough. Secondary objectives are: To study the inhalation maneuvers of patients using TIP in the home situation; to…
Primary objective: to evaluate the image quality between the two protocols using Signal to Noise Ratio (SNR) measurements Secondary objectives: 1) test if measurements of lung volume and central airways dimensions using MRI are related to validated…
Primary objective:To investigate the clinical response to treatment with curcumin and genistein in CF-patients with a class III S1251N mutation.. Secondary objectives:1.To evaluate the correlations between individual curcumin+genistein induced CFTR…
To compare the oxygenation and oxidative metabolism in skeletal muscles of patients with CF with healthy controls to provide insight in the metabolism in patients with CF.
Primary:To investigate the intravenous pharmacokinetics of [14C]-GSK2239633 in healthy male subjectsTo compare total radioactivity (drug-related material) in plasma relative to parent plasma concentrationTo determine total radioactivity (drug-…
Primary Objective: The purpose of this pilot study is to determine cut offs for both Procalcitonin and MR-proADM in stable CF patients. These measurements will be compared with Procalcitonin and MR-proADM values in CF patients with a pulmonary…
Research of lung function and exercise capacity in late preterms (32-36 weeks gestation) in comparison with term born controls of 8 years
The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…
We hypothesised that cardiovascular changes already exist in children with cystic fibrosis compared with healthy control children. Therefore, we will evaluate the cardiovascular system in a group of children with cystic fibrosis compared with…
Primary Objective: To determine the prevalence of endo- and extranasal deformities, problems with nasal functioning and satisfaction with nasal appearance in patients with TCS.Secondary Objective: To adjust and improve the treatment of patients with…
To determine the reliability and feasibility of the Nanoduct sweat test system compared to the gold standard tests QPIT and Macroduct.
To determine the succes rate of the Nanoduct sweat test system.
The study the influence of two different inhalationflow manoeuvres on the lungdeposition in patients with cystic fibrosis categorized to patientgroups varying in FEV1 longfunction value and age.
The purpose of this study is to examine the efficacy and safety of 26 weeks treatment with inhaled mannitol in subjects with cystic fibrosis. Previous studies with inhaled mannitol have demonstrated improvements in lung function, mucociliary…
• To define mediators involved in the early induction of COPD in susceptible smokers (and so to define new drug targets)• To develop new biological and clinical markers for the early diagnosis and monitoring of COPD• To characterize the switch to…
1. To develop a method that lets us derive measures of air trapping and emphysema from static CT that are independent of inspiration level.In order to achieve this objective we need to:2. study the influence of inspirational level on the extent of…
Primary objective: *What is the effect of an incremental maximal exercise test on inflammation in patients with cystic fibrosis and in healthy people?*Secundary objectives:- What are the differences in basal immune values between HP and CF patients…
To investigate in COPD whether: 1. systemic inflammation and multi-organ disease is more pronounced in more severe COPD2. quadriceps oxidative capacity and fiber type I proportion is reduced, and whether age, sex, smoking, physical activity, GOLD…