14 results
Primary Safety Objective * Proportion of patients who complete 24 weeks of combination treatment on pirfenidone at a dose of 1602*2403 mg/d and nintedanib at a dose of 200*300 mg/d Secondary Safety Objective * Proportion of patients who discontinue…
The main purpose of this study is to assess whether the study drug anetumab ravtansine is more effective than treatment with vinorelbine in patients with stage IV, mesothelin overexpressing malignant pleural mesothelioma. Efficacy will be measured…
Primary Objective:* To determine if TTFields in combination with pemetrexed/platinum improves overall survival (OS) compared to historical control in patients with unresectable mesothelioma.Secondary Objectives:* To evaluate the overall response…
Primary objectiveTo detect the difference in mean arterial blood pressure between conventional APRV settings and APRV settings based on EIT measurements, in patients with ARDS.Secondary objectivesImproved dorsal ventilation distribution on EIT…
Primary objective:Investigate whether the use of a digital drainage system leads to a shorter hospital stay in patients with primary pneumothorax, in whom clinical drainage is indicated. Secondary objectives: To investigate whether the use of a…
Primary objective- To define the optimal pressure support level for homogeneous lung ventilation during PSV, based on EIT measurements, in patients with and without lung disorders.Secondary objectives- Improved oxygenation compared to baseline-…
We expect to finalize the current phase I study by the May 2008 demonstrating that injection of tumor lysate-pulsed autologous DCs injected in patients with MM after chemotherapy is safe and well tolerated with induction of immune responses. New…
To evaluate the efficacy of manual aspiration in comparison to conventional chest tube drainage in pneumothorax therapy:1.whether the lung will expand by means of clinical and radiological findings.2.whether manual aspiration will shorten hospital…
This is a prospective, multi-center, randomized, two-arm, single-blind post market study designed to compare standard tissue closure techniques (control) to standard tissue closure techniques plus the PleuraSeal Sealant System (study device) for…
MAIN QUESTIONIs there any difference in the lungfunction of those people, who have undergone surgical intervention since 1985 in relation to a childhood empyema, compared to the refence population?Which determinants caused a degraded pulmonary…
Primary Objectives:• To compare progression free survival (PFS) as determined by blinded independent central review (BICR) and overall survival (OS) of nivolumab combined with ipilimumab to pemetrexed plus cisplatin or carboplatin regimen as first…
To describe criteria on CLE-imaging of different entities (thoracic wall/ pleura/ fibrosis/ mediastinum) compared to histology.
To demonstrate that removal of drains exclusively based on digital drainage system data is non-inferior to additional clamping trials regarding recurrent pneumothorax requiring chest tube reinsertion.
To investigate the feasibility of immediate P/D followed by cisplatin/pemetrexed chemotherapy (or carboplatin/pemetrexed chemotherapy) or deferred P/D after cisplatin/pemetrexed chemotherapy (or carboplatin/pemetrexed chemotherapy) in patients with…