61 results
The primary objective is to choose the dose (100, 150 or 200 mg/kg body weight) of tyrosine that shows the highest increase in plasma tyrosine concentration, based on comparison of the dose-response curves, in elderly. These dose-response curves…
The main objective of this study is to assess more thoroughly the differences in gait patterns between COPD patients and healthy controls. Other objectives are to assess differences in gait patterns between GOLD stages and two age groups in healthy…
To assess the effects on knee pain, function, quality of life and change in structural features with respect to cartilage and subchondral bone of osteotomy surgery after one year of follow-up compared to the effects of treatment with an orthopaedic…
This study will investigate the effects of renal nerve stimulation before and after percutaneous transluminal renal denervation on cardiac excitable properties including induction of ventricular tachy-arrhythmias before and after renal denervation…
The primary objective is to investigate cerebral perfusion in rest and in response to moderate exercise (handgripping or light cycling) and a visual stimulus in patients with severe aortic valve stenosis prior and after surgical or transcatheter…
Assess if CIN prophylaxis for CTA and a TAVI procedure with a 1 -hour sodium bicarbonate protocol is non-inferior in terms of decline in eGFR and serum creatinine level to the 24 hour saline protocol. in pre-operative screening for TAVI and actual…
Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…
To determine the reproducibility and validity of specific outcome measures for skeletal and respiratory fatigability in subjects with SMA.
To evaluate the clinical role of MRI/TRUS fusion target biopsy on prostate cancer detection, compared with other target biopsy strategies, in men with a persistent clinical suspicion on prostate cancer and at least one negative TRUS guided biopsy…
The main objective of this study is to determine the role of freeze-fight-flight reactions in the development and maintenance of PTSD symptomatology.
a. To establish the effects of (1) body weight support (2) treadmill speed, and (3) level of guidance/ movement support, on the neuromuscular control of the lower extremities in patients with post-stroke hemiparesis, and to determine possible…
Primary Objective: To compare the standard IM rod with the flexible IM rod in terms of post-operative sagittal contour of the distal femur. Secondary Objective(s):To compare the standard IM rod with the flexible IM rod in terms of post-operative…
Will the hyaluronic acid injections have impact on pain reduction and functional improvement in patients with osteoarthritis of the hip ?
The primary aim of this study is to investigate the recovery of the circadian rhythm of the hypothalamic-pituitary-adrenal axis during a glucocorticoid tapering regime. Secondary objectives include the effect of a tapering regime on melatonin rhythm…
1) For workers on sick leave due to subacute or chronic musculoskeletal pain, is a 40 hours vocational rehabilitation program non-inferior on work participation compared with a 100 hours vocational rehabilitation program? 2) For workers on sick…
The number and severity of adverse drug reactions (renal function, nausea and tremor) of cyclosporine using AUC targeted Therapeutic Drug Monitoring as compared to C0 targeted TDM.
The effectiveness of PRP treatment in patients suffering from chronic lateral epicondylitis is still ambiguous. Therefore we study PRP treatment in a double blind randomized controlled trial in a homogeny patient population with respect to duration…
The main objective of this study is to measure executive functions at two levels. First we will compare the results of neuropsychological testing in elderly with autism and compare these findings to elderly without autism. Secondly we will compare…
To investigate the differences in driving performance and safety between CD patients and healthy controls in a driving simulator. To compare the subjective evaluation of the difficulty of various aspects of the driving task driving in CD patients…
Aim of the study is to evaluate the effectiveness and cost-effectiveness of a positivity training based on attention bias modification as waitlist-intervention for adult outpatients with a major depressive disorder.