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OPtimal stEnt deployment stRategy oF Contemporary sTents

Primary objectiveThe primary objective is to evaluate whether a standard pre- and postdilatation of the modern DES results in a more optimal stent implantation compared to DS as evaluated by OCT in patients with stable coronary artery disease.…

Tailored vs Anatomical Ablation Strategy for Persistent AF

In this study, our objective is to demonstrate that a tailored ablation strategy targeting areas exhibiting spatio-temporal dispersion in association with PVI, is superior to an anatomical probabilistic ablation strategy targeting PVI alone for the…

Longstanding Exercise Therapy in Patients with Rheumatoid Arthritis

This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with RA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more effective…

Longstanding Exercise Therapy in Patients with axial Spondyloarthritis

This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability.There are 2 research questions to be addressed 1. Is longstanding, optimized active exercise therapy more…

Online Cognitive Behavioral Therapy-Enhanced: Guided self-help versus screen to screen for Binge Eating Disorder, A Randomized Controlled Trial

This study compares the efficacy of guided self-help CBT-E with to screen-to-screen CBT-E in terms of robust remission at end of treatment and during follow up. Robust remission will be defined as eating disorder pathology below a clinical cut-off…

Treatment considerations for the surgical therapy of peri-implantitis

The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…

Single Blind Randomized Phase III Trial to Investigate the Benefit of a Focal Lesion Ablative Microboost in Prostate Cancer

- Primary study objective: To demonstrate the superiority of the ablative microboost dose schedule regarding 5-year biochemical no evidence of disease rate compared to the current standard of care.- Secondary study objectives: Establish and compare…

Research into EMDR for Military Personnel and Veterans with Psychological Trauma

The primary objective is to study the effectiveness of EMDR in comparison to PE for treating military personnel and veterans with psychological trauma. Secondary objectives are:1. to investigate if working memory capacity is a predictor of EMDR…

A web based cognitive behavioral therapy that addresses gender
dysphoria, gender minority stress and suicidality among gender minority youth. A Randomized Control Trial

Research question:To what extent is a web-based, Cognitive Behavioral Therapy (CBT) specially designed for young gender diverse youth in the Netherlands, an effective treatment to reduce their suicidality? Are there gender, sex assigned at birth,…

HIPPI shoulder - Hip-allograft In Proximal humerus fractures versus Plate Implantation alone: a randomized controlled trial

The aim of this RCT is to examine the differences in functional, clinical, and radiological out-comes, between LCP fixation alone and femoral allograft augmentation in addition to LCP. Ultimately, the purpose is to optimize treatment strategies and…

A Prospective, Multicenter, Randomized Clinical Investigation Evaluating the Safety and Efficacy of ETHIZIA* versus SURGICEL® Original in Controlling Minimal, Mild, or Moderate Soft Tissue Bleeding During Open Abdominal, Retroperitoneal, Pelvic, Thoracic (Non-cardiac), and Extremity Surgery

The randomised safety and efficacy assessments of ETHIZIA are currently being evaluated in ongoing IDE trials where ETHIZIA is compared to TachoSil and SURGICEL® Original during open and minimally invasive liver surgery, respectively. This soft…