133 results
The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.
1. To investigate a possible increase intimal-media thickness (IMT) is found of the iliacal artery in endofibrosis2. To investigate a possible altered distention is found of the iliacal artery in endofibrosis3. To compare IMT and distention…
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
To investigate whether long-term activation of the innate immune system, named *trained innate immunity*, occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with…
In this exploratory study we aim to explore the values of apolipoprotein B bound to erythrocytes in patients with diabetes mellitus type 1 or 2, to evaluate the relationship with clinical and subclinical atherosclerosis and to compare these results…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
Main objective of this pilot study is to investigate the placental bed histological phenotype and evaluate a scoring system for lesion characteristics of the placental bed spiral artery in pre-eclampsia and uncomplicated pregnancy. The secondary…
The purpose of this study is to make it possible to make a prediction of risk of amputation stump wound healing without the need for re-intervention and whether a secondary amputation.
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
- To determine the difference in baseline mucosal oxygen saturation measurements and after luminal feeding between patients diagnosed with CGI and healthy subjects. - To determine the difference in baseline mucosal oxygen saturation measurements…
the aim of this study is to compare the impact of an early-CR within 48 hrs. after PPCI to a late complete revascularization >2 weeks after PPCI on LV remodelling in patients with STEMI and multi-vessel disease.
To investigate the relationship between C3 and vitamin D in adipose tissue and serum in morbidly obese subjects and in subjects who lost weight due to bariatric surgery.
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
To investigate the innate pro-inflammatory response in young patients (<50 years of age), who suffer from a myocardial infarction. The pro-inflammatory response will be examined by the search for *trained immunity* especially in the monocytes…
This study aims to provide a comprehensive assessment of global coagulation parameters in patients with ASC both in hospital and up to 12 weeks after discharge. The results will help define the period at risk for VTE and inform the rationale for…