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AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

The purpose of the pivotal study is to determine the safety and efficacy of IMPEDE-FX RapidFill for increasing the percentage of subjects with shrinkage of the abdominal aortic aneurysm sac when used as an adjunct to on-label EVAR stent graft…

Randomized controlled clinical trial on the application of Heli-FX EndoAnchors in conjunction with the Endurant II/IIs endograft in infrarenal aortic aneurysms with a wide infrarenal neck

The primary objective of this study is to investigate if the use of Heli-FX EndoAnchors in conjunction with placement of aortic stent grafts under instructions for use (IFU) conditions in aneurysms with a wide neck is superior to treatment with…

Gadolinium-enhanced aneurysm wall imaging of unruptured intracranial aneurysms: a follow-up study

Primary objective: To investigate if the presence of aneurysm wall enhancement predicts aneurysm instability in the long-term. Secondary objective: To investigate if the absence of aneurysm wall enhancement predicts aneurysm stability in the long…

TRansfusion strategies in Acute brain Injured patients: TRAIN Study; A Prospective Multicenter Randomized Interventional Study

The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…

Blood oxygen level dependent (BOLD) magnetic resonance imaging technique to predict buttock claudication in patients undergoing endovascular abdominal aorta aneurysm repair (EVAR) with coiling of the internal iliac artery.

The goal of this study is to investigate whether BOLD MRI can predict the occurrence of buttock claudication after coiling of the internal iliac arty. The BOLD technique will be used to measure blood supply parameters of the gluteal muscle during…

Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with *Minimally-
Invasive Staged Segmental Artery Coil- Embolization*: A Randomized Controlled Multicentre Trial

The primary objective is to greatly reduce incidence of ischaemic spinal cord injury (SCI, potentially resulting in permanent paraplegia) and mortality - the most devastating complications resulting from open surgical and thoracoabdominal…

Endothelial Colony Forming Cells, Endothelial Progenitor Cells and Bicuspid Aortic Valves: in vitro culture of peripheral blood cells to study biomarkers and pathogenesis in BAV?

The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…