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A randomized, open-label, parallel-group, multi-center study of adding edoxaban or clopidogrel to aspirin to maintain patency in subjects with peripheral arterial disease following femoropopliteal endovascular intervention-edoxaban in peripheral arterial disease (ePAD)

The aim of this study is to evaluate whether adding edoxaban to aspirin following femoropoplitealendovascular intervention will enable maintenance of vessel patency and prevent restenosisrelative to current treatment with clopidogrel and aspirin.

IMPACT:
Does the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in
asymptomatic patients undergoing carotid artery stenting prior to cardiac surgery who are being pre-treated with either a 300 mg or a 600 mg loading dose of clopidogrel?

Firstly, to investigate whether the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in patients who are being pre-treated with either a 300 mg or a 600 mg loading dose…

An open label, active comparator extension trial to assess the effect of long term dosing of inclisiran and evolocumab given as subcutaneous injections in subjects with high cardiovascular risk and elevated LDL C (ORION-3)

Primary:• To evaluate the effect of inclisiran treatment on low density lipoprotein cholesterol (LDL-C) levels at Day 210 compared to Day 1 of this extension study. Secondary:• To evaluate the effects of inclisiran on the following: LDL-C levels…

Anatomical mapping and assessment of tissue perfusion using indocyanine green near-infrared fluorescence in patients with peripheral arterial disease.

The main objective of this study is to asses the applicability and validity of ICG parameters in the diagnostic work-up in patients with peripheral arterial disease. We will also asses the applicability of ICG-NIRF in intra-operative assessment of…