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Clinical effectiveness of standard versus pathogen-reduced buffy coat-derived platelet concentrates in plasma in hemato-oncological patients;Pathogen Reduction Evaluation & Predictive Analytical Rating Score (The PREPAReS Study)

A prospective randomized phase III clinical trial to study the effectiveness of pathogen-reduced platelet concentrates in plasma, stored for up to 7 days, and compare these with untrested platelet concentrates in plasma, stored for up to 7 days. The…

Effects of a structured progressive task-oriented circuit training program to enhance walking competency after stroke

The primary aim of this study is to evaluate the effects of a structured, progressive task-oriented fitness training program applied in a group of 8 to 10 patients on perceived outcome of mobility after stroke when compared to individually-tailored…

Revised Evaluation of Surgery in Elderly with Traumatic Acute SubDural Hematoma (RESET-ASDH study)
Survival and quality of life after early surgical intervention versus wait-and-see in elderly patients with a traumatic acute subdural hematoma (ASDH): an international multicenter prospective cohort study

To compare the (cost-)effectiveness of early surgical hematoma evacuation versus a conservative treatment in elderly patients with a traumatic ASDH.

IMPROVING OUTCOME IN SUBARACHNOID HEMORRHAGE WITH NADROPARINE

This study has been transitioned to CTIS with ID 2024-511679-14-00 check the CTIS register for the current data. Our primary objective is to evaluate whether aSAH patients treated with therapeutic dose nadroparine have a lower 30-days mortality rate…

A Randomized Clinical Trial of Andexanet Alfa in acute intracranial haemorrhage in patients receiving an oral factor Xa inhibitor

In oral FXa inhibitor-treated patients with acute intracerebral bleeding, the objectives of this study are as follows:Primary Efficacy Objective:To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…

Medication (de)prescribing in hospitalized geriatric patients with sarcopenia, less is more?

The effects of DPA compared to STOPP-START approach (SSA) prescribing on adverse drug reactions, medical complications, hospital readmission, quality of life in hospitalized geriatric patients with sarcopenia

Effectiveness of a REhabilitationprogram to treat fatigue in patients who suffered from a SubArachnoid Haemorrhage (RE-SAB); a pilot study

Primary aim: Examine whether and to what extent fatigue and quality of life of patients with SAH improve after participating in RE-SAB.Secundary aims: (1) Examine whether and to what extent physical activity level, physical fitness, coping style,…

A phase 4 Randomized Clinical Trial of Andexanet Alfa [Andexanet Alfa for injection] in acute intracranial haemorrhage in patients receiving an oral factor Xa inhibitor

In oral FXa inhibitor-treated patients with acute intracranial bleeding, the objectives of this study are as follows:Primary Efficacy Objective:• To evaluate the effect of andexanet versus usual care on the rate of effective hemostasis.Secondary…

Does virtual reality gait training improve participation after a stroke?

The objective of this study is to investigate the effect of virtual reality training, given between 2 weeks and 6 months after stroke, on participation and subjective physical functioning in independently living patients .Primary research question:…

Implicit and explicit motor learning during gait rehabilitation and the use of simple technologies to support independent gait training at home in people after stroke.

The objective of this study is twofold. The first objective is to study the effectiveness of implicit motor learning on walking speed in clients after stroke in daily practice. The second objective is to determine the technology acceptance,…