737 results
This study aims to investigate if endoscopic trans-sphenoidal prolactinoma resection as a first line treatment (PRolaCT-1), or as an equally valid second line treatment after a short (2-12 months) or long (>12 months) period of pretreatment…
To generate high quality empirical evidence for the effectiveness in terms of proportion of patients experiencing complications, quality of life and costs of initial non-operative treatment strategy (reserving appendectomies for those not responding…
The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable CRLM (<=3cm) and no extrahepatic disease.
Aim: to develop, implement and evaluate COMBO to improve SDM during the treatment trajectory of TC patients in situations when clear cut recommendations cannot be made either because the benefits closely balance with risks, or because this balance…
To assess whether HBOT reduces pain, and improves physical functioning and QoL in breast cancer patients with late radiation toxicity.
The DEPTHip Study aims to shed light on the question whether the use of a continuous ultrasound-guided FICB employing catheter technique, administered in the ED within 2 hours after presentation of an elderly patient with a hip fracture, can…
With this study we will be able to determine whether the DAA has better short-term results compared to the PLA in THA whilst improving patient outcome and reducing costs for hospitals and society as a whole.
The aim of this study is to compare health status, quality of life outcomes and subjective postoperative pain for patients with severe aortic stenosis treated either with a limited access aortic valve replacement or with a conventional aortic valve…
Our primary objective is to compare the effects of cyclic DBS with continuous DBS in OCD patients on 1) symptom severity. Secondary, we will compare the effects on 1) battery life 2) adverse events 3) cognitive performance 4) cortical EEG…
There is a high degree of diversity in attributed risk on thrombosis in the neurosurgical patient cohort. Due to this diversity, insufficient power of performed studies and lack of careful phenotyping and description of risk factors in previous…
This study aims to determine the effectiveness of a new breast reconstruction technique: Autologous fat transfer (AFT). This technique combines the advantages of using the patients* own tissue (fat cells), while being minimally invasive compared to…
To determine cost-effectiveness of hepatic venous pressure gradient (HVPG)-guided nonselective beta-blocker therapy as compared to standard heart rate-guided beta-blocker therapy in the primary prevention of esophageal variceal bleeding in cirrhotic…
To compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients receiving a lower extremity amputation with standard neurectomy versus those who received targeted muscle reinnervation.
The objective of this study is to quantify the subjective feeling of knee (in)stability during a stair descent. This results in the following research question:*Is there a relation between the kinematics of the knee joint from people who suffer from…
To demonstrate that immediate fixation leads to a shorter total rehabilitation period and to less stiffness at final follow-up after SL reconstruction.
To assess the post-operative quality of recovery after robot-assisted as compared to open extended lateral pancreaticojejunostomy.
Identifying the (immune) cell composition, co-localization, functions, and alterations as well as blood and lymph vessels reorganisation in the human*s dura, arachnoid and pia mater, and skull bone marrow in high-grade glioma patients as compared to…
The main objectives of this study are to investigate to what extent:1) VRT and MT can contribute to pain reduction compared to patients who receive no VRT and MT intervention during complex wound care; and2) VRT can contribute to pain reduction…
Primary objective: Investigation of mean peak plantar pressure at the location of the diabetic foot ulcer and at 6 plantar regions of the foot (i.e. hallux, digits, first metatarsal, second to fifth metatarsals, midfoot, and heel) during total…
To determine the value of and generate the clinical evidence for routine application of Whole Genome Sequencing (WGS)-based diagnostics and targeted therapy guidance for glioblastoma patients at time of first recurrence.