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Transfusion of fresh frozen plasma in non bleeding ICU patients

With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…

A Randomized Controlled Multicenter Study of an Incisionless Operating Platform for Primary Obesity vs. Diet-Exercise alone: The MILEPOST Study

The primary objective of this study is:* To evaluate the safety and effectiveness of the g-Cath* EZ Delivery Catheter with Snowshoe Suture Anchors* gastric procedure as an weight loss intervention compared to diet and exercise only.A key secondary…

Cortrak bedside Or Regular Endoscopic placement of nasoenteral feeding tubes in surgical patients (CORE): a randomized controlled multicenter non-inferiority trial

To determine the (cost-)effectiveness and budget impact EM-guided bedside placement as compared to endoscopic placement of a nasoenteral feeding tube in surgical patients.

Sensation in children with an Obstetric Brachial Plexus Palsy

The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…

Remifentanil use for procedural sedation and analgesia in the emergency department

Answering the following questions:1. Main question: Is remifentanil a usefull medication for PSA in the emergency department?2. What is the recovery time of the patient when using fentanyl / propofol / remifentanil (time between last gift PSA…

Optimizing the intermanual transfer effects after training with a prosthetic simulator

The objective of this study is to determine the optimal myo-electric prosthesis training for obtaining the largest transfer effect. Here fore we plan to execute three experiments. At first it needs to be revealed which trainingtasks leads to the…

Radiological evaluation of CT based vs MRI based Signature* for total knee arthroplasty

PrimaryTo evaluate the alignment of the Signature* CT-based procedure compared to the Signature* MRI-based instruments.SecondaryTo evaluate the efficacy of the CT-based Signature* procedure in terms of operation time compared to the Signature* MRI-…

Anterior cruciate ligament CT study:
Transtibial, anteromedial portal, tape locking screw reconstruction technique

The main objective of this study is to compare the femur tunnel positioning after AMP, TLS and TT reconstruction techniques. We will also look at the relation between tunnel positioning and tunnel widening.

*Omega-3 fatty acids in bariatric gastric bypass surgery: effects on liver volume, immune response and erythrocyte function*

Our primary objective is to compare pre-treatment with the standard low calorie diet with pre-treatment with supplemental omega-3 fatty acids on liver volume. Secondary objectives are patient satisfaction about different dietary pre-treatments, the…

Randomized Study of IN.PACT Amphirion* Drug Eluting Balloon
(DEB) vs. standard PTA for the treatment of below the knee critical
limb ischemia [IN.PACT DEEP]

1. Evaluate safety and clinical and angiographic efficacy of BTK revascularization with IN.PACT Amphirion* randomized to standard, uncoated PTA balloons2. Assess the clinical efficacy of BTK revascularization with IN.PACT Amphirion* compared to a…

Comparative roentgen stereophotogrammetry analysis (RSA) between the conventional Mallory- Head stem in primary uncemented total hip replacement compared to two shorter variations

Objective: To perform a comparative assessment between the clinical, bone remodelling, and radiographic outcomes (as measured with RSA) of the conventional Mallory-Head stem compared two shorter versions of Mallory-Head stems in patients undergoing…

The clinical relevance of axillary reverse mapping (ARM)

The objective of the study is to determine the clinical relevance of sparing the lymfdrainage of the upper extremitiy by using the ARM-procedure in patients with breast cancer. The purpose of the continuation of the feasibility study is to create a…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Joint distraction (KJD) in treatment of knee osteoarthritis: cartilage changes in a comparison with a presently applied surgical alternative: high tibial osteotomy (HTO)

1. To compare cartilage changes after KJD and after HTO, based on MRI, radiographs and biomarkers, evaluated 2 years post treatment. 2. To compare clinical efficacy after KJD and after HTO during 2 year follow-up by a questionnaire (KOOS; for pain,…

A multi center, prospective, randomized controlled trial comparing cervical arthroplasty to anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease.

The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial CervicalDisc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index(NDI) and neurological function…

A prospective single-blinded randomized multi-center clinical trial comparing the clinical efficacy and patient acceptability of open selective haemorrhoidopexy with stapled haemorrhoidopexy

The purpose of this prospective randomised trial is 1) to compare short- and long-term efficacy of open selective haemorrhoidopexy with stapled haemorrhoidopexy; 2) to compare patients satisfaction between open and stapled haemorrhoidopexy.

Perforator based interposition flaps for sustainable release of scar contractures: a reliable, simple and versatile technique.

A randomised controlled multcenter trial is performed to evaluate the perforator-based interposition plasty in comparison to full thichness grafts for scar contracture releases.

Supervised Exercise Therapy or Endovascular Revascularization for Intermittent Claudication due to an iliac artery obstruction.

The primary objective is to compare initial PTA with supervised exercise therapy for patients with disabling intermittent claudication due to an iliac artery lesion in terms of mobility, functional status, health related quality of life and cost-…

Biomarkers as predictors of wound healing after lower leg amputations in patients with severe peripheral arterial disease.

The purpose of this study is to make it possible to make a prediction of risk of amputation stump wound healing without the need for re-intervention and whether a secondary amputation.

Reperfusion-induced self-antigen excretion (RISE) following major liver resection

To investigate the release of damage-associated molecular patterns (DAMPs) following major hepatic resection with or without VIO and to correlate the outcomes to the acute inflammatory response and clinical parameters for hepatocellular damage.