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A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

Single Incision Laparoscopic Versus Existing Resection (Minimal Access) for Neoplasia
A Multi-institutional Randomised Controlled Trial

Objective: To compare patient outcome following standard of care (laparoscopic right hemicolectomy) and an alternative, established, recognized therapy (SILS right hemicolectomy) for the treatment of right colonic tumors.

Conventional tonsillectomy versus outpatient CO2-lasertonsillotomy in adult patients; a randomised controlled trial

The purpose of this study is to demonstrate the effectiveness of treatment using the CO2-laser in one selected group of patients compared with a classical tonsillectomy. We also compare peri-operative en post-operative morbidity, pain, complications…

Treatment of subcutaneous abdominal wound healing impairment after surgery without fascial dehiscence by Vacuum-Assisted Closure® (V.A.C. ® SAWHI-Study) versus standard conventional wound therapy

The primary objective of this multicenter, parallel design, prospective, randomized clinical trial, with repeated observations over time, is to compare the clinical, safety, and economic outcomes of V.A.C.® Therapy and SCWT based on an open…

Catheter ablation versus Amiodarone to pRevent Future ventricular tachycardia Episodes in patients with a defibrillator and a history of a myocardial infarction

Time to recurrence of sustained VT and/or appropriate ICD therapy; ATP or shock

Midterm results open versus closed wedge high tibial osteotomy: a follow-up study

Our primary objective is to compare the midterm clinical and radiographic results (6 to 8 years) of CWO versus OWO with a locked plate fixation in the management of patients with medial knee OA and a varus leg alignment with a prospective follow-up…

A randomised clinical trial comparing minimal invasive (MIS) total knee replacement (TKR) with conventional total knee replacement

Objective: Does minimal invasive total knee replacement has (at least) comparable or better results to conventional total knee replacement if looked at functional recovery, complications and pain.Amendement 1: measure the accuracy of the cementing…

The effects of Suprathel® versus a calcium alginate on pain perception and comfort in split-thickness skin graft donorsites.

The primary objective of this research is to compare pain experience and comfort when a calcium alginate or Suprathel® is used on the donor site. Secondary objectives are the differences in scarring, itching of the scar tissue and costs involved…

A randomized European Study Comparing Endoluminal Stent grafting and best medical Therapy (BMT) to BMT Alone in the Traetment of Acute Uncomplicated Type B Aortic Dissection

Objective of the study: The primary objective of this study is to assess the efficacy See primary endpoints, section 7.1 of endoluminal stent grafting and BMT compared to BMT alone in the treatment of uncomplicated acute type B aortic dissections.

UNA PATELLA PARTICULARE
Patellar resurfacing in total knee arthroplasty: a randomized controlled clinical trial

Primary outcomeThe primary objective of the study is to evaluate if patients undergoing resurfacing of the patella during TKA show at least 10 % improvement in the Baldini score (after 24 months) compared to patients undergoing TKA without…

Endoscopic Stenting versus Operative Intervention in Malignant Gastric Outlet Obstruction(STENTOP), a multi-center randomized controlled trial.

To investigate which treatment modality is preferable in patients with an irresectable malignant gastric outlet obstruction: endoscopic stent placement or a surgical gastrojejunostomy.

Dutch Arthoscopy Association Rotator Cuff Study

The objective is to evaluate and compare the outcome of conventional open or arthroscopic rotator cuff surgery, by means of clinical scores and biomechanical studies (range of motion, scapulohumeral rhythm, muscle activation patterns).

SMMaC trial: a prospective validation study of Sentinel lymph node biopsy in patients with Multicentric Mamma Carcinoma.

The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.

Laparoscopic Sleeve Gastrectomy versus laparoscopic Roux-en-Y Gastric bypass trial for Morbid Obesity.

Objective: The primary objective is to evaluate if %EWL after LSG as bariatric therapy is equal or, within an acceptable margin, inferior to LRYGB. Secondary objectives are to evaluate QOL, cure /improvement of obesity related co-morbidity (i.e. DM-…

The occurrence of cerebral embolism (CE) in catheter ablation of atrial fibrillation (AF) using three different ablation catheters

1. To compare the induction of a procoagulant state between patients undergoing PVI using the PVAC catheter, the cryoballoon catheter or the cooled tip catheter.2. To compare the incidence of CE on diffusion weighted MRI between the three groups of…

Bard® PolySoft* pre peritoneal mesh versus Parietene* ProGrip* self-fixing semi-resorbable mesh and chronic inguinal pain development.

Objective of the Trial:Does the use of a Bard® Polysoft* preperitoneal mesh result in less chronic pain than after the use of a ProGrip*self-fixing semi-resorbable mesh for patients with an inguinal hernia repair through an anterior approach?

Antecolic versus retrocolic route of the gastroenteric anastomosis after pancreatoduodenectomy: ARCO-trial

Primary objective:To determine the relationship of route of gastroenteric anastomosis after PD and postoperative incidence of DGE.Secondary objectives:To determine the relationship of route of gastroenteric anastomosis after PD and gastric emptying…

Volumetric Wear Measurements in Total Knee Arthroplasty; Cross-linked versus Standard Polyethylene insert

The objective of this research is to investigate in vivo by means of RSA the amount of wear of the insert very secure.Through frequently taken RSA measurements over a 3 year period, we might be able to predict the longevity of the XLPE insert.

The efficacy of radioguided occult lesion localisation (ROLL) versus wire guided lesion localisation (WGL) in breast conserving surgery for non palpable breast cancer: a randomised controlled trial

To evaluate the efficacy of ROLL versus WGL in breast conserving surgery for non-palpable breast cancer.

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…