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Pericardial Tissue and the Post Pericardiotomy Syndrome

1. To get new insights in the pathophysiology of PPS by comparing tissue characteristics (histology) of the pericardium in patients with and without PPS. 2. To identify biomarkers that are associated with PPS by collecting 4 blood- and 1 pericardial…

Right Atrial Pacing versus Left Atrial Pacing to Prevent Development of Paroxysmal Atrial Fibrillation in Patients with Sick Sinus Syndrome or Anti-arrhythmic Drug-induced Bradycardia.

- To determine the effects of the pacing site on prevention of AF episodes - To examine the relation between the pacing site, reduction of AF episodes, quality of life, heart failure, number of cardioversions, frequency and duration of hospital…

The occurrence of cerebral embolism (CE) in catheter ablation of atrial fibrillation (AF) using three different ablation catheters

1. To compare the induction of a procoagulant state between patients undergoing PVI using the PVAC catheter, the cryoballoon catheter or the cooled tip catheter.2. To compare the incidence of CE on diffusion weighted MRI between the three groups of…

Comparison of cerebral tissue oxygen desaturation in patients undergoing on-pump or off-pump coronary artery bypass grafting

The goal of this study is to determine if off-pump CABG surgery is associated with better cerebral tissue oxygenation when compared with on-pump CABG. In addition, we would like to compare the results of two different monitors of brain tissue…

Perioperative changes in the microvascular perfused boundary region in patients undergoing coronary artery bypass grafting

To identify the influence of two different biocompatible-coated extracorporeal circuits on the perfused boundary region of the sublingual microvasculature as measured by the GlycoCheck Sidestream Darkfield Imaging camera.

Chronic post-sternotomy pain, relation between accompanying painsymptoms and painlocation on the sternum

The objective of this study is to prove that chronic post-sternotomy pain is not a local painproblem, but part of a general painsyndrom.Our hypothesis is twofold:1. The investigated painsymptoms are of more frequently occurrence in the pain-sample…

Neonatal thymectomy; consequences for homeostasis and regulation of the immune system?

This study observes the immune system of children and adults who have been without a thymus for 3 to 30 years. Our objective is to study the role of the thymus in the developing immune system. In addition this study will give insight in the long…

Predicting by means of in vitro tests the treatment response in patients with MG

The first aim of this study is to use an in vitro approach using patient*s derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients. The second aim of this…

Quantifying Electropathology in Adult Patients with Congenital Interatrial Communications
an endocardial mapping study

to quantify atrial electropathology of the endocardium in adult patients with CHD and to correlate clinical characteristics, atrial volume, electropathology, atrial ectopy and features of pre- and post-procedural atrial fibrillation.

Body mass index and microcirculatory behavior in patients undergoing cardiac surgery with cardiopulmonary bypass

Primary objective: Is there a difference in the change in perfused vessel density between obese and lean subjects after cardiac surgery with cardiopulmonary bypass?Secondary Objectives * Is there a difference in baseline perfused vessel density…

Cerebral injury after neonatal cardiac surgery: Outcome at school age

To gain insight in the cerebral consequences of neonatal cardiac surgery.