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Long-term follow-up of the prospective and comparative study of the performance of tension free vaginal mesh (ProliftTM) versus conventional pelvic organ prolapse surgery in recurrent prolapse

To asses the effectiveness of surgery 7 and 10 years after conventional vaginal POP surgery compared with tension free vaginal mesh.

RCT comparing insertion of levonorgestrel releasing intrauterine system (Mirena) during the menstruation compared with random insertion beyond menstruations in patient-perceived pain.

In this randomized study, timing during (day 1-7 of the menstruation cycle WITH vaginal blood loss) or beyond menstruation (in menstruation cycle day 8 and further WITHOUT vaginal blood loss) will be compared regarding differences in patient-…

A randomized, single blinded trial to evaluate the efficacy of Imiquimod in women with residual/recurrent Cervical Intraepithelial Neoplasia (CIN) after previous treatment

Primary objectives: Evaluation of the efficacy of imiquimod 5% cream compared to treatment with Large Loop excision of the transformation zone (LLETZ) for recurrent/residual CIN.Secondary objectives: evaluation of the effect of treatments on HPV DNA…

Patient controlled analgesia i.v. with morphine versus continuous epidural analgesia with bupivacaïne and sufentanil as pain relief after caesarean section.

We would like to research wether there is a difference in time of mobilization between women getting iv PCA with Morphine (PCA)as opposed to women getting continuous epidural analgesia (CEA)with bupivacaine and sufentanil.We expect that the PCA will…

Prospective study on the treatment of congenital vaginal agenesis or vaginal hypoplasia - genital reconstruction, gynecological and urological aspects, psychosexual and social aspects and quality of life

Evaluation study on the effectiveness of a new developed vaginal dilatation programme for medical-psychological treatment of vaginal hypoplasia / agenesis.

A randomized controlled multicenter phase III trial comparing cytoreductive surgery followed by intravenous chemotherapy versus intravenous chemotherapy alone for recurrent platinum-sensitive ovarian cancer

There is still no level I-II evidence for cytoreductive surgery in recurrent ovarian cancer. This is also the conclusion of a Cochrane Review of Galaal et al. published in June 2010. The most active chemotherapy in platinum sensitive recurrent…

The role of immunology in diabetes mellitus and pregnancy

Primary Objective: To determine the local and peripheral immune response in diabetic pregnancies in comparison to healthy controls. Immune response will be measured by counting Th1/Th2-cells, Tregs, NK-cells, monocytes and granulocytes. Produced…

A PROSPECTIVE AND COMPARATIVE STUDY OF THE (COST) EFFECTIVENESS OF TENSION FREE VAGINAL MESH PLUS MONOCRYL (PROLIFT+MTM) VERSUS CONVENTIONAL VAGINAL PROLAPSE SURGERY IN PRIMARY PROLAPSE

To compare the clinical and cost effectiveness of the Tension free Vaginal Mesh + Monocryl (Prolift+MTM) with the standard vaginal prolapse surgery (i.e. fascial placation). A secondary objective is to track the post-operative and long-term…

Sacrospinous ligament fixation combined with anterior colporrhaphy versus Elevate Anterior procedure in treatment of primary apical and anterior compartment prolapse stage >= 2: a multi-center randomised controlled trial.

To compare the effects of sacrospinous ligament fixation combined with anterior colporrhaphy versus Elevate Anterior procedure on pelvic floor function.

A prospective multi-national randomized comparison of the effectiveness and safety of MiniArc and Monarc.

To randomly compare MiniArc and Monarc for:* efficacy as surgical correction of stress-incontinence* post-operative pain* complications* morbidity and post-operative recovery* the need for repeated stress-incontinence surgery or specialized…

Electrosurgical bipolar vessel sealing using LigaSure versus conventional clamping and suturing for vaginal hysterectomy: a randomized controlled trial

To randomly compare the effects of vessel sealing LigaSure on the operative parameters, post-operative pain and recovery and post-operative function of the pelvic floor in vaginal hysterectomy,

Primary treatment of vaginal prolapse, pessary use versus prolapse surgery. A comparison of quality of life.

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Pretherapeutic para-aortic lymphadenectomy in advanced stage cervical cancer.

1. To study the safety and feasibility of para-aortic surgical staging in advanced cervical cancer in the Netherlands.2. To provide insight in the possible effectiveness of para-aortic surgical staging in advanced cervical cancer as compared to…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

In vitro maturation of human oocytes with subsequent IVF or ICSI . An observational study with follow up of the children.

The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…

A randomized controlled trial of anterior colporraphy and PerigeeTM as surgical correction of symptomatic cystocele.

To study which technique is most effective to surgically correct a symptomatic cystocele.2. To compare morbidity and post-operative recovery of anterior colporraphy and PerigeeTM.3. To compare the need for repeated pelvic floor surgery following…

A comparison of the efficacy of levobupivacaine 0,125%, ropivacaine 0,125% and ropivacaine 0,2%, all combined with sufentanil 0.5 micrograms/mL, in patient-controlled epidural analgesia after hysterectomy under combined epidural and general anesthesia

to compare the analgesic efficacy of levobupivacaine and ropivacaine in patient-controlled epidural analgesia, as assessed by the number of requests for epidural bolus injectionsto compare visual analogue scale (VAS) scores and neural block…

A randomised controlled trial comparing the clinical and cost-effectiveness of the Avaulta anterior mesh and the standard anterior colporraphy for the primary surgical treatment of a cystocele stage >= 2

To compare the clinical and cost-effectiveness of an anterior colporraphy repair with a cystocele repair with the use of the non-absorbable synthetic Avaulta® mesh.

A multi-centre randomised comparison of the effectiveness and safety of TVT-O and TVT-S.

1. To compare the effectivity of TVT-O and TVT-S as surgical correction of stress-incontinence. 2. To compare the complications of TVT-O and TVT-S.3. To compare the morbidity and post-operative recovery of TVT-O and TVT-S. 4. To compare the…