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Effect of Multiple healthy donor intestinal microbiota infusions on non Alcoholic Steatosis Hepatis (NASH) and vascular function in obese subjects

In this study we would like to investigate whether repetitive allogeneic (lean donor) fecal transplantations can reduce liversteatosis and if so which (small) intestinal bacteria cause this inflammation in the liver resulting in subsequent chronic…

A multicenter, randomized, blinded efficacy and safety study of pasireotide LAR vs octreotide LAR in patients with metastatic carcinoid tumors whose disease-related symptoms are inadequately controlled by somatostatin analogues.

To compare the long term efficacy of pasireotide LAR vs. octreotide LAR at month 6 in controlling diarrhea and/or flushing in patients with metastatic carcinoid tumors whose disease-related symptoms are inadequately controlled by the maximum…

A randomized, double-blind, multicenter, phase III study to evaluate the efficacy and safety of pasireotide LAR in patients with Cushing*s disease

To assess the efficacy and safety of two Pasireotide LAR regimens in CD patients.

A randomized, double-blind placebo-controlled, multicenter phase III study in patients with advanced carcinoid tumor receiving Sandostatin LAR and RAD001 10 mg/Day or Sandostatin LAR and Placebo

To determine whether treatment with RAD001 10 mg/d plus Sandostatin LAR® prolongs the progression free survival (PFS) compared to treatment with Sandostatin LAR® alone in patients with advanced carcinoid tumor.

A phase III, randomized, double-blind, active-controlled, non-inferiority clinical trial to investigate the efficacy and safety of a single injection of Org 36286 (corifollitropin alfa) to induce multifollicular development for controlled ovarian stimulation using daily recombinant FSH as a reference

38819: To investigate the efficacy and safety of a single injection of Org 36286 to induce multifollicular development for COS using daily recFSH as a reference.38821: To evaluate whether Org 36286 treatment for the induction of multifollicular…

Effect of donor Intestinal Microbiota Infusion on Thyroid function in patients with autoimmune HypOThyreoidism

To investigate whether microbial transplantation from either allogenic (healthy) or autologous (own) donor, administered every 8 weeks during 6 months through a small intestinal tube, has beneficial effects on residual thyroid function at baseline,…

MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women with Polycystic Ovary Syndrome: a multicentre double-blind randomised controlled trial

The primary objective of this study is to assess the effectiveness of myo-inositol supplementation to prevent pregnancy complications in women with PCOS. Secondary objectives are to evaluate the impact of supplementation on maternal (mental) and…