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Primary aldosteronism in general practice: organ damage, epidemiology and treatment

Objectives: Part 1) To assess the prevalence of PA in general practice (part 1 of this study);Part 2) To describe differences of cardiorenovascular damage in newly diagnosed hypertensive patients with versus without PA (part 2 of this study);Part 3…

The microcirculation in children treated with extracorporeal membrane oxygenation;
an observational longitudinal study

To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…

prospective longitudinal assessment of cardiovascular toxicity of childhood cancer treatment

Primary objectives1. To investigate prospectively the prevalence of cardiovascular damage due to cancer treatment and it*s change over time.2. To investigate markers of early and late toxicity of cardiovascular damage due to cardiotoxic treatment.…

T-Cell Mediated Plaque Inflammation and Atherosclerosis in Stage III Melanoma Patients on (neo-)adjuvant Immune Checkpoint Inhibitors: a prospective matched cohort study

To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…

Fetal myocardial deformation assessed by speckle tracking; a longitudinal cohort study in the (ab)normal pregnancy;Substudy: fetal heart rate variability and ECG waveform parameters in the IUGR pregnancy

To investigate the effect of increasing gestation on fetal myocardial deformation values.To explore fetal heart rate variability and fetal ECG waveform parameters in both healthy and growth-restricted fetuses, measured with non-invasive fetal…

Periodontitis as a potential early risk indicator for diabetes mellitus, atherosclerotic cardiovascular disease, metabolic syndrome and obstructive sleep apnea syndrome

The aim of the proposed study is to screen for (pre)DM, an increased 10-year-risk of ASCVD, MetS and a high risk of OSAS in subjects with and without periodontitis. Consequently, the dental office will be evaluated as a suitable location for early…

The influence of the menstrual cycle on diagnostic results of cardiovascular diseases - The Cycle Study II

To investigate whether the menstrual cycle influences diagnostics in patients with cardiovascular disease

Replacing Conventional Chest X-Ray Imaging with Ultra-low-dose CT: The REPLAiCE Study

The primary objective of the study is to investigate the medium to long term effects of replacing the conventional CXR exam with an ultra-low-dose CT in terms of patient health.Secondary outcomes are measures are • Quantity and type of follow-up…