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Effect of donor human milk on severe infections and mortality in VLBW infants, a double blind randomized controlled trial

To determine whether (supplemental) human donor milk has beneficial effects (in terms of reduction of infectious episodes and mortality) when compared to (supplemental) preterm formula during the first 10 days of life in VLBW infants. Amendement ESS…

Clinical and microbiological evaluation of different implant surface decontaminating procedures in the surgical treatment of peri-implantitis; a randomized controlled study

The primary objective of this controlled clinical study is to evaluate the clinical effect of decontamination of the implant surfaceduring the surgical treatment of peri-implantitis using a 35% phosphoric acid gel or saline.The secondary objective…

A prospective, multinational, multicenter, randomized, double-blind, double-dummy, controlled study comparing the efficacy and safety of moxifloxacin to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbations of chronic bronchitis: MAESTRAL (moxifloxacin in AECB superiority trial)

The primary objective is to compare the efficacy of moxifloxacin 400 mg PO OD for five days with the respective efficacy of amoxicillin clavulanic acid 875/125 mg PO BID for seven days in the treatment of subjects with AECB. The primary efficacy…

Characterization Of Resistance Against Live-attenuated diarrhoeagenic E. coli

Primary Objective: In the CORAL study we want to determine whether increasing the inoculation dose of diarrhoeagenic E. coli to 5*10^10 CFU and addition of a second challenge 1*10^10 CFU will result in an increased effect-size and duration of…

GIGA Study: Gastrointestinal benefit of dairy Ingredients to prevent symptoms of Gut infection in healthy Adult subjects

To investigate whether minimally processed milk product can decrease the diarrheagenic E. coli-induced changes in reported stool frequency and gastrointestinal complaints.

Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY): A Multi-Center Randomized Controlled Study Comparing Alternative Antibiotic Regimens in Patients Undergoing Tumor Resections with Endoprosthetic Replacements

The objective of this study is to determine whether long term (5 days) postoperative (cefazolin) antibiotics will decrease the rate of infection following lower extremity tumor surgery, when compared to short term (24 hours) postoperative (cefazolin…

MIRRE STUDY: The protective immune response to attenuated enterotoxigenic Escherichia coli infection in healthy human subjects: a pilot study.

Aim of the MIRRE pilot study is to determine how much the primary inoculation dose of diarrheagenic E. coli should be lowered in order to result in a reduced protective response upon a secondary infection.

PRF vs EMD periodontal regenerative surgery : a double blind, randomized controlled trial on the treatment of furcation II involved molars

Compare PRF and EMD regenerative potential in the surgical treatment of molar teeth with periodontal destruction in the furcation area.Evaluate induced Healing potential of the two materials. Correlate healing pattern with biomarkers in blood and…