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Bioavailability of oral ciprofloxacin tablets versus suspension in pediatric cancer patients

To determine the relative bioavailability of ciprofloxacin oral suspension versus oral tablets in pediatric cancer patients, and to determine the absolute bioavailability of tablets and suspension utilizing the 100% bioavailability of intravenous…

Q Herpen II, Post outbreak screening in a Q fever high incidence area for late consequences of Q fever including chronic Q Fever.

This study will provide a robust estimate of the prevalence of C. Burnetii exposure and possible chronic Q fever among asymptomatic participants. This is important in order to assess whether population screening in a high incidence area is useful…

Sinonasal pathology in children with Cystic Fibrosis

Investigation of the prevalence of sinonasal disease on CT-sinus in children with Cystic Fibrosis at different ages. This study will focus especially on the onset of sinonasal pathology in Cystic Fibrosis in relation to the development of the…

Second meningococcal vaccination in Dutch children: Study to compare the tetravalent MenACWY-TT conjugate vaccine with the monovalent MenC-TT conjugate vaccine.

The aim of this study is to investigate the immune response to a tetravalent MenACWY-TT vaccine in 10-, 12- and 15-year old children primed with the monovalent MenC-TT conjugate vaccine at a young age and to1. determine whether the MenC-specific…

Implementation of a cost effective strategy to prevent neonatal infection by group B-hemolytic streptococcus

To find the most cost effective GBS prevention strategy to reduce neonatal morbidity and mortality by GBS for the Netherlands.

Prevention of recurrent urinary tract infections by multi-drug resistant bacteria, by intravesical administration of gentamicin.

Objective: The main objective is to demonstrate superiority of the intravesical overnight instillation of gentamicin versus oral antibiotic prophylaxis in reducing the number of recurrences of UTI and extending the time-interval to a next UTI, in…

CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients.
The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study.

OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.

Cognitive bladder training versus rectal washout training for girls with recurrent urinary tract infections and urinary incontinence

Research question: is primary aggressive treatment of constipation with rectal wash-out in girls with NNBSD at least equally effective as usual care?

Characterization of veterinary and community acquired MRSA: determinants, transmissibility and virulence

The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.

An explorative randomized open-label trial of ethanol lock therapy for the additional treatment of catheter-related bloodstream infections (CRI) in pediatric parenteral nutrition patients with intravascular devices

To study the effect of ethanol lock therapy on the cure rate of catheter-related infections (CRIs) and on the incidence of (CRI related) venous thrombosis in pediatric total parenteral nutrition (TPN) patients with tunneled central venous catheters…

Methicillin-resistant Staphylococcus aureus: Occupational exposure, dynamics of carriage and associated disease in livestock farmers and their household members.

Primary objective: To determine the dynamics of MRSA carriage in persons working on or living at pig and veal farms.Secondary objectives: To determine the amount of disease associated with carriage of MRSA-CC398. To determine the role of exposure to…

Circadian Influence on Renal Clearance of Aminoglycosides in cystic fibrosis patients

Main objective: To compare the renal elimination rate constant in CF patients receiving a daily intravenous dose of tobramycin in the morning against patients receiving a daily intravenous dose of tobramycin in the evening. Secondary objective: To…

Treatment of recurrent Clostridium difficile infection with fecal therapy:
the FECAL trial (Fecal enema to Eliminate Clostridium difficile Associated Longstanding diarrhea)

With this study we will investiagate the superiority of fecal clysma therapy (n=34 patients) above conventional therapy with the antibiotic vancomycin (n=34 patients) or bowellavage with conventional antibiotic therapy (n=34 patients).

Reducing the prescription of antibiotics in newborn infants suspected for having an early onset sepsis.

Our preliminary data shows that the prescription rate of antibiotics for suspected EOS versus blood culture proven EOS was high. We aim to develop a new diagnostic model to reduce unnecessary antibiotic treatment which can be tested in the near…

The role of immune evasion cluster (IEC) encoded proteins in Staphylococcus aureus (S. aureus) nasal colonisation

This study aims to define the role of the IEC in S. aureus colonisation.

Clinical parameters and biomarkers in blood and urine as predictors for bacteremia, hospital admission, morbidity and outcome in patients with complicated urinary tract infections.
A study in primary care, the medicine emergency room and ICunit.

Establish relevance of a clinical scoring system, and of established and to be identified biomarkers in blood and urine for clinical course and clinical and microbiological outcome of patients with a complicated urinary tract infection, treated in…

Specific B-cell Memory After a Single Dose or Booster MenC Conjugate Vaccination: a Pilot Study in Adults

How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…

In vitro activation of monocytes from pregnant women by different types of bacterial lipopolysaccharides leads different immunological pathways

Objective of this study is to investigate cytokine production and expression of toll-like receptors on monocytes in blood samples from pregnant and non-pregnant women using sonicates from different types of oral pathogenic micro-organisms and…

Ketanest In Septic Shock

Primary Objective: To compare ketanest induction and maintenance to etomidate induction and maintenance with midazolam and fentanyl on hemodynamic, ventilatory and endocrine parameters during the first 2h after the diagnosis of sepsis and in need of…

Spread of veterinary MRSA in The Netherlands

The primary objective of this study is to determine the prevalence of V-MRSA in areas with high density of pig farming compared to the expected prevalence of MRSA in the general population of The Netherlands and as a secondary objective to assess…