20 results
To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
This study aims to determine whether the ILC populations differ in the lungs of different phenotypes of asthmatic patients and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to study how this is…
The primary objective is to explore the association between peripheral T-cell activation and apoptosis and hepatic fibrosis in various underlying liver diseases. Secondary objectives are 1) to investigate whether level of T cell activation and…
To examine neurocognition in 100 HIV1 seropositive patients on chronic effective cART using three different tests: the Montreal cognitive assessment (MoCA) , the International Aids Dementia scale (ADS) and extensive neuropsychological testing of…
The main objective of this study is to compare DTI findings of PPS patients with those of healthy controls. Secondary objective of this study is to correlate DTI findings with clinical data such as isometric muscle strength. Third objective is to…
Primary objectives:(1) To describe the incidence of EV and HPeV infections in Dutch children(2) To determine the major symptoms of EV/HPeV infections in children(3) To evaluate the epidemiology and symptoms of the different subtypes of EV and HPeV(4…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
In this study we clinically validate if host cell DNA methylation markers can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance and the safety of withholding treatment. This could prevent…
The goal of this study is to develop a flow-cytometric assay that is able detect antigen-specific B-cells to rabies vaccine.
To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for a…
1. The primary objective is to evaluate whether Ser-Col for SARS-CoV-2 antibody detection is an acceptable alternative for standard venous blood collection. 2. The secondary objective is to compare SARS-CoV-2 antibody detection in (venous and…
The aim of the present study is to investigate if the high negative predictive value of the Colab-score hold on when investigating this score in the following cohort of persons:- Care- and cure-personnel of Zuyderland MC who were requesting a SARS-…
The primary objective of this study is: to develop a blood vessel-on-chip model that mimics hypercoagulability in patients with COVID-19. The secondary objective is: to evaluate the efficacy of agents that inhibit COVID-19-related hypercoagulability…
The primary objectives of this project are the identification of biomarkers in the blood and skeletal muscle that can improve the diagnosis of viral myocarditis and the expansion and improvement of the viral diagnostics in these patients. However,…
The primary objective is to determine the quantity and quality of antibody and T-cell responses to SARS-CoV-2 in asymptomatic patients who tested positive for SARS-CoV-2 with RT-PCR prior to interventions. The secondary objectives are:- To determine…
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
The primary objective of the main non-inferiority study is to determine the safety of TACmono starting nine months after kidney transplantation in immunologically low-risk patients in terms of BPAR-rate 15 months after transplantation compared to…