195 results
Examining the applicability of a fieldable serological point of care serological test Biozek and Point of care molecular Fluorescent in Situ Hybridization (FISH) technology by Biotrack for the usage of decision making, containment and management of…
The results of this research contribute significantly to the field of Travel Medicine, especially for elderly travelers who have been vaccinated with YF-17D at 60 years or older, and who are planning to visit a yellow fever endemic country in the…
Primary:To demonstrate the non-inferior antiviral activity of switching to a two drug CAB LA 400 mg + RPV LA 600 mg regimen every 4 weeks compared to remaining on ABC/DTG/3TC (or DTG and an approved dual-NRTI scheme) over 48 weeks.Secondary:To…
Primary objectivesTo evaluate the efficacy, feasibility, viro-immunological kinetics and safety following the administration of ConvP as a therapy for outpatients diagnosed with COVID-19 at increased risk for an unfavourable clinical outcome and…
To evaluate the efficacy of convalescent plasma compared to standard plasma to improve an ordinal outcome as primary endpoint: consisting of shorter than the average of 6 days hospital stay, no admission to the intensive care unit (ICU), no need for…
Elucidation of the pathogenic role of cornea-infiltrating HSV-specific T-cells in HSK patients.
The primary objectives of this project are the identification of biomarkers in the blood and skeletal muscle that can improve the diagnosis of viral myocarditis and the expansion and improvement of the viral diagnostics in these patients. However,…
Primary objective:To assess pharmacokinetic similarity of EBR/GZR as a crushed (test) Zepatier tablet compared to a whole (reference) tablet.Secondary objective:To assess Cmax similarity of EBR/GZR as a crushed (test) Zepatier tablet compared to a…
The primary objective is to determine the quantity and quality of antibody and T-cell responses to SARS-CoV-2 in asymptomatic patients who tested positive for SARS-CoV-2 with RT-PCR prior to interventions. The secondary objectives are:- To determine…
Primary objective: To evaluate, in a cohort of non-tested individuals who reported flu-like symptoms during the COVID19 epidemic in the Netherlands (March-November), the seroprevalence of COVID19 in patients with an IMID, with or without…
In this study, we therefore aim to establish the kinetics of the humoral immune response against SARS-CoV-2, and relate this to the viral characteristics, microbiome and host factors of healthcare workers.
The objectives of this study:• To generate the proof of concept for lanadelumab for treatment of symptoms of COVID-19 disease • To demonstrate its safety after intravenous administration.
To answer the following questions: 1. Who are the patients that need to be revaccinated?2. How many vaccinations are needed to restore SARS-CoV-2 immunity?3. Can the number of vaccinations needed to restore SARS-CoV-2 immunity be predicted?To answer…
Primary Objective: - To assess the effect of MMR-0 vaccination on the humoral immunity against measles 2 years (+/- 2 months) after MMR-2 vaccination.Secondary Objective(s): - Determine the effect of MMR-0 vaccination on the humoral immunity against…
The primary objective is to evaluate the proportion of patients with HCV RNA below the level of quantitation (target not detected [TND] or target detected, not quantifiable [TDnq]) at 12 weeks post end of treatment (SVR12) following sofosbuvir/…
In the Phase 2 clinical study, the efficacy of the vaccine in non-responders and the safety of the vaccine will be studied.
Primary: To demonstrate the non-inferior antiviral activity of switching to DTG + RPV once daily compared to continuation of current antiretroviral regimen (CAR) over 48 weeks in HIV-1 infected antiretroviral therapy (ART) experienced subjects.…
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
To investigate whether addition of PEG-IFN alfa-2a in HBeAg-negative chronic hepatitis B patients who are pretreated with NA enhances the degree of HBsAg decline
More knowledge on immunity to VZV in these patient groups is necessary to be able to design preventive strategies to VZV infections in the future. To reach these goals, the proposed study is divided into two parts. The first part aims to determine…