195 results
To study a cohort of HIV infected and HIV uninfected MSM and HIV infected heterosexuals who (subsequently) acquired HCV infection with a known date of HCV seroconversion:1. To identify the frequency, clinical consequences and determinants (viral and…
To investigate the association of ITPA genotype and ITPase activity with nephrotoxicity, bone toxicity and recovery of nephrotoxicity and bone toxicity during and after anti-retroviral treatment with a tenofovir containing regimen for HIV.
Primary objective:To assess the bioequivalence of SOF/VEL as a crushed (test) tablet compared to a whole (reference) tablet in patients treated with SOF/VELSecondary objective:To evaluate the safety and tolerability of crushed SOF/VEL tablets in…
The aim of the POLO study is to evaluate pharmacokinetics and safety of a single-dose of dolutegravir in patients with severe hepatic impairment (Child-Pugh score * 10) and compare these to matched controls.
To identify genetic host factors associated with HCV susceptibility among HIV-infected MSM.
The primary objective of this study is to compare the safety, overall tolerability, and virologic response of BCV vs. SoC (i.e., investigator-assigned therapy) for the treatment of AdV infection in high-risk pediatric allogeneic HCT recipients. A…
1. Evaluation of neurocgnitive functioning in children with HIV in comparison with healthy siblings using questionnaires.2. Qualitative analysis of different determinants that play a role in school participation in children with HIV using interviews…
ALICE is a randomised controlled trial in Primary Care that aims to determine whether adding antiviral treatment to best usual primary care is effective in reducing time to return to usual daily activity and so the clinical and cost effectiveness of…
The aim of this study is to demonstrate that a single dose of rabies vaccine can induce an equally rapid and adequate anamnestic antibody response as 2-dose PrEP to revaccination six months later.
To study the renal safety when HIV patients with TDF related renal toxicity switch to TAF compared to the current practice of switching to ABC.
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
The primary objective of the main non-inferiority study is to determine the safety of TACmono starting nine months after kidney transplantation in immunologically low-risk patients in terms of BPAR-rate 15 months after transplantation compared to…
With this research we aim at gaining more insight into the reason for the fact that some individuals reconstitute well during cART whereas other do not. Also, we would like to investigate what mechanism is responsible for reconstituting the CD4 T-…
Primary objective:To assess the bioequivalence of single-dose velpatasvir administered as a fixed-dose combination of sofosbuvir/velpatasvir (SOF/VEL; Epclusa®) when given with cola + omeprazole 40mg (test 1/trt A) compared to velpatasvir…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.