15 results
The aim of our study is to measure 1) the prevalence of signs of child abuse and neglect in children with functional defecation disorders, 2) whether signs of child abuse and neglect are more common in children with functional defecation disorders…
Primary:- To identify causal genetic variants and proteomes involved in achalasia and to study their relevanceSecundary:- To build-up a large scale harmonized biobank of achalasia patients, based on combining existing and new data from the European…
To identify chromosomal regions associated with the GERD-phenotype in a large multigenerational family with multiple affected members. Subsequently these regions will be sequenced to detect causative gene(s). The second aim is to describe the…
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
To investigate the underlying mechanisms of gastroesophageal reflux and gastroesophageal reflux symptoms in treated achalasia patients.
To study the diversity and functionality of intestinal microbiota of patients with IBS over time in comparison with asymptomatic controls.
Our Objective is to show that the administration of prokinectics leads to an altered position of the acid pocket scintigraphically, and it thereby changes the rate of postprandial acid reflux episodes.
We hypothesise that the increased permeability of the esophageal mucosa in GERD patients can be shown using confocal laser scanning fluorescence microscopy. This difference in esophageal permeability may prove a diagnosticum for patients without…
To determine incidence, aetiology and course of gastroenteritis in case of hospitalisation with gastroenteritis. To gain insight in pathogen-specific duration, seriousness of the disease (including complications), and mortality. To investigate…
To investigate a) the functional role of chloride secretion in constipated adults (Ussing chamber studies) and b) inventory possible aberrancies in in situ ClC-2/ CFTR expression levels by immuno-histochemistry staining techniques.
To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…
The aim of this study is to validate an IBS-specific electronic patient-reported outcome measure, based on the Experience Sampling Method-principle, for symptom assessment in IBS. The objectives, therefore, are to establish the validity and…
Aim of the present study is to set up a large cohort of IBS patients in order to identify different disease characteristics as well as aetiological and pathophysiological factors in (sub)groups of patients with this heterogeneous disorder. Various…
In this study we would like to investigate whether fecal transplantation, administered through a nasoduodenal tube, from either allogenic or autologous donors, has beneficial efffects on IBS symptoms such as abdominal pain intensity and frequency,…