126 results
The primary objective of this efficacy and safety study is to demonstrate that tight control of disease activity using stringent criteria based on CDAI, hs-CRP, fecal Calprotectin, and corticosteroid use improves the rate of mucosal healing 48 weeks…
Evaluate the efficacy of the combination therapie with azithromycin and metronidazole in a randomized trial
To evaluate the effect of parenteral supplementation of fishoil based emulsion (rich in omega-3 fatty acids) compared with a soy bean oil emulsion (rich in omega-6 fatty acids) on the leukocyte functions (amongst others production of TNF-α and other…
To ex vivo assess the difference in effect of administration of NSAIDs, PPISs and SSRIs on the paracellular permeability of colon biopsies (i.e. change in trans-epithelial electrical resistance) between active, remission and non-MC patients, using…
This study aims to provide a comprehensive assessment of global coagulation parameters in patients with ASC both in hospital and up to 12 weeks after discharge. The results will help define the period at risk for VTE and inform the rationale for…
To evaluate the efficacy and safety of infliximab dose reduction guided by serial trough level measurements, compared to treatment as usual (no dose reduction), in Crohn*s disease patients who are in stable remission with infliximab maintenance…
To assess the safety of lengthening the adalimumab dosing interval from 2 to 3 weeks, in patients with Crohn*s disease or ulcerative colitis in long term (6 months) remission.
Primary: To demonstrate that a liquid Neocate product (elemental nutrition) study decreased esophageal eosinophil count to less than 15 eosinophils per high-power field in adult patients with eosinophilic esophagitis.Secondary: To study the effect…
To show that in eosinophilic oesophagitis gastro-oesophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic cells activates…
In a dose escalation study we will determine the safety and preliminary efficacy of allogeneic bmMSCs in the induction of response for active fistulizing CD.
Primary objectives1. What is the effect of stopping mesalazine in the maintenance setting of patients with quiescent CD?2. Can subgroups of CD patients, for example based on prior treatment (medical vs. surgical), localization of disease, disease…
The aim of our project is in-depth characterization of the microbiota components both adjacent to and within the mucosa in patients with IBD, by applying novel high-throughput analysis technology in a global description strategy approach.…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
Setup method for detection of STAT3 phosphorylation in human blood derived from patients with various chronic inflammatory diseases.Test the effect of new compounds on this phosphorylation process.
The overall objective of this study is an improvement in (early) diagnosis of NEC and its life-threatening complications, thus to be able to detect children who are *at risk* for NEC and its complications as early as possible. To this end we will as…
Primary: We hypothesize that in eosinophilic esophagitis gastro-esophageal reflux-induced epithelial barrier dysfunction facilitates passage of food-antigens through the epithelial barrier and subsequent increased exposure of antigens by dendritic…
Evaluate the benefits, risks and costs of early surgical intervention as an alternative to current step-up practice for CP.
1) To identify chromosomal regions associated with the EoE-phenotype in a family with multiple affected family members. Subsequently these regions will be sequenced to detect causative gene(s).2) To describe the clinical characteristics of EoE-…
To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.
To study the effectiveness of gut-directed hypnotherapy in the treatment of IBS-like symptoms in patients with inflammatory bowel disease.