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Vedolizumab in PSC and concurrent IBD: Searching for the missing link between the gut and the liver and exploration of biomarkers for development of colorectal carcinoma.

To test the hypothesis that vedolizumab has chemopreventive properties with regard to colorectal neoplasia in the high-risk group of patients with PSC/IBD.

Oral versus intravenous iron in IBD patients with anti-inflammatory therapy

Regarding the current recommended once daily dosing of oral iron (with probably less side effects than with a 3 times daily dose), and the decrease of hepcidin in patients on immunosuppressive medication, we hypothesize that patients with mild to…

Optimising surgical anastomosis in ileocolic resection for Crohn's disease to reduce recurrent disease: A Randomized controlled trial comparing hand-sewn (END-TO-END or Kono-S) to stapled anastomosis (END2END study)

To understand if handsewn (end to end and Kono S side to side) anastomoses is superior to side to side stapled anastomosis after ileocolic resection for Crohn's disease with respect to endoscopic recurrence, gastrointestinal function and costs.

A phase 3, multicenter, Randomized, Efficacy Assessor-Blinded study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects With Moderate to Severe Crohn*s Disease who have failed anti-TNF therapy.

This study has been transitioned to CTIS with ID 2022-501645-70-00 check the CTIS register for the current data. Part 1:The objective is to compare the efficacy and safety of risankizumab versus ustekinumab over 48 weeks for the treatment of adult…

Long-term hepatotoxicity of azathioprine, 6-mercaptopurine and 6-thioguanine in IBD patients

Assess hepatotoxicity of long-term azathioprine and 6-mercaptopurine use in IBD-patients as compared with a cohort of long-term 6TG users

Deep profiling of lipid changes in patients with active ulcerative colitis treated with either tofacitinib or infliximab

To evaluate the tofacitinib and infliximab treatment-induced changes in plasma lipids and lipoproteins and to provide insight in the underlying mechanism in relation to the inflammatory status in patients with active UC.

Mental functioning, brain Tryptophan availability and affect; the role of the immune system

The primary objective of the study is to explore whether immune activation potentiates stress vulnerability by increasing serotonin dysfunction (lower tryptophan ratio*s). This objective is based on the hypotheses that pro-inflammatory cytokines…

Risk-stratified randomized controlled trial in paediatric Crohn*s Disease: Methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or at high risk for aggressive disease course, respectively * a treatment strategy

To compare the effectiveness of weekly subcutaneously administered MTX for maintaining relapse-free sustained steroid/EN-free 1-year remission compared with:- daily oral AZA/6MP in low risk paediatric CD- subcutaneously administered adalimumab in…

The Effect of a Multimodal Lifestyle Intervention on Chronic Fatigue in Patients with Inflammatory Bowel Disease

Objective: to investigate if a multimodal lifestyle intervention reduces chronic fatigue and improves quality of life in patients with IBD.

Subcutaneous vedolizumab drug de-escalation using therapeutic drug monitoring in inflammatory bowel disease: a randomized controlled pilot study

This study has been transitioned to CTIS with ID 2024-517502-28-01 check the CTIS register for the current data. Our explorative pilot study wants to observe whether TDM can attribute to an efficient dose de-escalation strategy of SC vedolizumab in…

A Phase 3, Multicenter, Randomized, Platform Study of p19 Inhibition of the IL-23 Pathway to Establish Efficacy in Pediatric Crohn*s Disease;ISA title: A Phase 3, Multicenter, Randomized Clinical Study to Evaluate Mirikizumab in Pediatric Crohn*s Disease

This study has been transitioned to CTIS with ID 2024-511472-32-00 check the CTIS register for the current data. Primary for Platform-Level Exploratory Analysis1. To evaluate whether treatment with IL-23 inhibitors is superior to adult placebo in…

Comprehensive assessment of the long-term effects of necrotizing enterocolitis and its treatment

To determine the long-term outcome after necrotizing enterocolitis during neonatal life, regarding (pain) sensitivity, sensory processing, behaviour, executive function, scar satisfaction (in surgically treated NEC patients), and (health-related)…

Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the Netherlands * The TWIN study

To gain insight in the disease mechanisms of IBD, the immune system, gut and oral microbiome, environmental factors, the intestinal mucus barrier, intestinal epithelium, nutritional factors and metabolome will be studied in unaffected siblings of…

A Phase 3, Multicenter, Randomized, Platform Study of p19 Inhibition of the IL-23
Pathway to Establish Efficacy in Pediatric Crohn*s Disease;ISA title: Efficacy, Safety, and Pharmacokinetics of Guselkumab in Pediatric Participants with
Moderately to Severely Active Crohn*s Disease

This study has been transitioned to CTIS with ID 2023-504735-41-00 check the CTIS register for the current data. Primary for Platform-Level Exploratory Analysis1. To evaluate whether treatment with IL-23 inhibitors is superior to adult placebo in…

Fluid hydration to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis: the FLUYT-prevent trial. a multicenter randomized controlled superiority trial.;Pancreatic duct stent placement to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in patients with unintended PD-wire cannulation: a multicenter prospective cohort

FLUYT: To investigate whether aggressive rehydration with RL during ERCP prevents PEP and will be cost-effective.FLUYT-2-PDS: To investigate if PDS placement further reduce the risk of the development of PEP in patients with unintended PD-wire…

Influence of JAK inhibitors on the disease-associated network of intestinal immune cells in ulcerative colitis

Observing changes in immune cell composition in locally (intestinal biopsies) and systemically (Peripheral Blood Mononuclear Cells (PBMCs)) upon JAK inhibitor treatment of UC patients.

Decoding personalized nutritional, microbiome and host patterns impacting clinical and prognostic features in Crohn*s disease

By means of this study we want to find out whether there are certain characteristics that can influence or predict the course of Crohn's disease. We want to do this by collecting data on diet, inflammation levels in the blood, complaints and…

GASTROESOPAHGEAL REFLUX DISEASE AFTER N-SLEEVE VERSUS ROUX-EN-Y GASTRIC BYPASS (GINSBY): A RANDOMISED CONTROLLED TRIAL

The aim of this study is to determine the effectiveness of N-sleeve in terms of a reduction of GERD in morbidly obese patients, compared to LRYGB.

The smell of a sick liver in primary sclerosing cholangitis

To comprehensively profile the VOCs pattern in patients with PSC to get more insight in the etiology/pathogenesis of the disease, in particular the role of inflammation and gut microbiome.

CyTOF analysis of novel mucosal immune cells in Inflammatory bowel disease: relation with disease phenotype and location.

1. Comprehensive phenotypic analysis and comparison of mucosal immune compartment in patients and controls ex vivo (year 1-3);2. Comprehensive phenotypic analysis and comparison of mucosal stromal cell compartment in patients and controls ex vivo (…