19 results
To assess whether the use of RFIB instead of LCNB increases the probability of a definitive preoperative histological diagnosis in women with suspicious mammographic breast lesions. assess the *RFIB success rate*, defined as the proportion of…
Reduction of the mean number of operations under general anaesthesia per patient. Improvement of Quality of Life. Reduction of depressive symptoms and experienced anxiety.
This study will investigate whether oligometastatic triple negative or BRCA1/2 related breast cancer can be treated effectively with a multimodality approach including induction chemotherapy, and whether high dose alkylating chemotherapy can improve…
The purpose of this study is to investigate whether the pre-operative contrast enhanced CT scan can be used for determination of the pre-operative tumour localisation, with the aim of increasing the accuracy of the boost area. If so, the boost…
Primairy objective: we will examine the difference in VOC pattern of exhaled air between patients with histology-confirmed diagnoses of non small cell lung cancer vs breast cancer. Secundairy objective: a. to confirm the potential of the electronic…
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
We will investigate if irradiation of part of the heart leads to cardiac sympathetic innervation injury and subsequently to radiation induced cardiovascular disease.
Primary objective phase II:To explore if there is an indication of a positive effect on local control rate of adding Cisplatin to local reirradiation and hyperthermia to patients with local regional recurrent breast cancer in previously irradiated…
Nearly all patients who die from breast cancer die from the consequences of distant metastases. Adjuvant chemotherapy, either administered before or after surgery, has been shown to reduce the risk of metastases and death. Four main groups of…
Primary Objective: To show superiority of a 0.1 mmol/kg dose of MULTIHANCE over a 0.1 mmol/kg dose of MAGNEVIST for breast MRI in terms of sensitivity for the diagnosis of malignant lesions compared with histopathology. Secondary Objectives: a)To…
The aim of this study is to investigate whether single nucleotide polymorphisms can increase the sensitivity and specificity of serum markers in breast cancer diagnostics.
The objective of this study is to evaluate the (nationwide and international) implementation of ICG-fluorescence for SN-procedures for patients with breast cancer.
The primary end-point is ipsilateral invasive breast tumor-free rate at 10 years. Secondary end-points are among others: overall survival, breast cancer-specific survival, mastectomy rate and patient reported outcomes.To determine whether low- risk…
- To study sensitivity and specificity of the MeD-seq test for detection of BrCa in female BRCA1/2 mutation carriers in an early stage.- To determine if the MeD-seq test can detect BrCa earlier in time than current surveillance tools (MRI/…
The INFINITE trail aims to successfully implement ICG-fluorescence for identifying the SLN by: 1) guiding the implementation process using the Effective Implementation of Change model developed by Grol and Wensing; 2) identifying and understanding…
Early detecction of breast cancer in women with high risk of developing breast cancer with protein and glycan biomarkers.
This study will investigates the effect of high dose alkylating chemotherapy compared to standard dose chemotherapy as part of a multimodality approach in patients with oligometastatic HRD positive and/or BRCA1/2 related breast cancer.
This phase II/III controlled multicenter trial will investigate the ability of individualized chemotherapy to improve the objective response rate of *triple-negative* breast cancer (estrogen receptor and progesterone receptor-negative, no HER2…
The primary objective of this study is to assess the univariate association between RILA frequency and RIF after BCT and radiotherapy among breast cancer patients. Secondary objectives include: the identification of treatment and patient related…