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Determination of phenotypical and biological characteristics of mesenchymal stem cells in pediatric myelodysplastic syndromes

1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…

Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation

We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.

Skeletal muscle glucose uptake in patients with chronic myeloid leukemia on tyrosine kinase inhibitor therapy

The current study aims to compare skeletal muscle glucose uptake after 1) an exercise stimulus and 2) under hyperinsulinemic conditions between CML patients on nilotinib, CML patients on imatinib and non-CML controls.