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Utility of BOLD MRI as diagnostic tool in renal artery stenosis in patients with hypertension and chronic kidney disease

Is the BOLD MRI able to show the difference in the level of oxygenation as a mesurement of ischemia between a in a healthy kidney (<30% renal artery stenosis) and a kidney with more than 70% artery stenosis?

Reducing costs of surveillance of patients with non-muscle invasive bladder cancer.

1) To prove that it is possible to safely reduce the number of invasive cystoscopies during follow-up (FUP) of patients with NMIBC with a low/intermediate risk of recurrence or progression. 2) To prove that addition of urine tests to the follow-up…

Non-invasive ultrasonic diagnosis of urinary Bladder Outlet Obstruction (BOO)

To study in a small group of male volunteers the feasibility of estimating urinary flow velocity and turbulence caused by obstruction using rf ultrasound. Subsequently, to compare in a group of patients eligible for TURP according to clinical…

Advanced MRI in renal tumours

To evaluate the diagnostic performance of diffusion weighted MR imaging (MRI) techniques by using apparent diffusion coefficient (ADC) maps and Diffusion Tensor Imaging (DTI) on 3 tesla MRI in assessing the nature of renal masses.

Pilot study into the endothelial function in paediatric renal transplant recipients by means of peripheral arterial tonometry

Ascertain feasibility, study burden, between-subject and within-subject variability of automated RH-PAT measurements in paediatric renal transplant recipients. Comparison of adipokines and inflammatory profiles in renal transplant recipients and…

Influence of the solution used for the long dwell on the results of the Peritoneal Equilibration Test using 3.86% glucose in CAPD.

The aim of the present study is to compare the following transport characteristics for a modified 3.86% glucose PET preceded by a long (>8 hours) dwell with 3.86% glucose (PET A) and one preceded by a long dwell with 7.5% icodextrin (PET B),…

Non-invasive evaluation of urinary bladder contractility and urethral resistance after ProACT treatment of stress urinary incontinence in men: a pilot study.

The aim of the present study is to investigate the possibility of the use of non-invasive methods for the evaluation of bladder outlet obstruction after ProACT* device implantation by comparing non-invasive measurements with invasive measurements.…

Bone - MRI in Renal Insufficiency

The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.

An exploratory study to evaluate bladder contractions in the storage phase (non voiding activities) and related bladder sensation in healthy females and untreated females with Overactive Bladder (OAB) using high resolution and conventional urodynamics.

To identify objective parameters to characterize Non Voiding Activity (NVA) in healthy and OAB subjects using high resolution urodynamic assessmentNVA are changes of pressure in the bladder lumen. These changes are measured as detrusor pressure (…

MRI of the sacral plexus and sacral nerve roots in children with neurogenous bladder dysfunction with sacral or spinal anomalies

Gain insight in the anatomy and organisation of the sacral plexus in children with NB and congenital spinal or sacral anomalies. Possible findings can be compared with the results of the healthy subjects, in order to be able to relate findings to…

CAMPUR study: CAtheter Managment and diagnostics for symptomatic Postpartum Urinary Retention

To compare which treatment (indwelling catheter versus intermittend catheterisation) has the best clinical effect in women with symptomatic PUR.

Influence of haemodialysis on the in vitro mitogenic function and interferon-gamma production of the CD4- and CD8-positive T-lymphocytes in patients undergoing chronic heamodialysis

To determine the general usefulness of and a proper moment when blood should be taken for the in vitro IFN-γ assays in patients undergoing chronic haemodialysis.

Evaluation of the pelvic floor patients with Pelvic Organ Prolaps (POP) and controls, using dynamic MRI and Diffusion Tensor Imaging (DTI).

In this study we aim to evaluate pelvic floor structures in both POP patients and controls with the use of different anatomical landmarks and reference lines in non-invasive dynamic MRI. Additionally we propose to evaluate the feasibility of DTI in…

The assessment of microvascular alterations in renal transplant recipients with and without rejection

Assessment of microvascular alterations using orthogonal spectral polarization and correlate this with markers for endothelial cell dysfunction, fibrosis and histology in patients with renal function impairment who will undergo renal biopsy and…

The multiparameter MLC-CFSE test to predict T cell-allo-immune reactivity in renal transplant recipients.

To select T cell properties intrinsic to the transplant recipient, which can discriminate between patients who will likely experience acute cellular rejection episodes from those who don*t.

Alpha-1-microglobulin to diagnose acute pyelonephritis

We want to prove wheter the A1M/creatinine ratio in the urine is a good marker to diagnose an APN, or not. The study design has been made of a prospective observational cohort, controlled by a DMSA-scan.Our aim is to use the A1M/creatinine marker in…

A phase 4, monocenter, randomized, open label, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 8-week treatment with the glucagon-like peptide-1 receptor agonist lixisenatide versus insulin glulisine on renal physiology and biomarkers in insulin glargine-treated patients with type 2 diabetes mellitus

Main study:Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the GLP-1RA versus a single dose prandial insulin onrenal hemodynamics (glomerular filtration rate/ effective renal plasma flow in basal insulin-…

PErirenal Adipose tissue and RenaL hemodynamics in patients with Heart Failure with Preserved Ejection Fraction

2.1 Primary objectiveThe primary objective is to determine whether perirenal adipose tissue thickness is increased in patients with HFpEF compared with age, sex and BMI-matched healthy controls2.2 Secondary objectivesThe secondary objectives are to…

The influence of sacral neuromodulation on brain areas involved in the sensation of bladder filling in patients with Overactive Bladder (OAB) using fMRI

2.1 Primary Objectives• To identify brain activation evoked by sensation in response to bladder filling in patients with an implanted sacral neurostimulator as a treatment for overactive bladder (OAB), compared to a baseline in OAB patients without…

Flow dysfunction of hemodialysis vascular access: a randomized controlled trial on the effectiveness of surveillance of arteriovenous fistulas and grafts

See above.