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A Multicentre, Open-Label, Single Ascending Dose, Dose-Ranging, Phase I/IIa Study to Evaluate the Safety and Tolerability of an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in Living Donor Renal Transplant Recipients.

This study has been transitioned to CTIS with ID 2024-512579-11-00 check the CTIS register for the current data. Primary:- To evaluate the short-term safety and tolerability of TX200-TR101 from the day of TX200 TR101 infusion within 28 days post…

Optimizing Access Surgery In Senior hemodialysis patients

To compare surgical strategies for vascular access creation in elderly hemodialysis patients.

Long-Term Follow-Up of Patients who have received an Autologous Antigen-Specific Chimeric Antigen Receptor T Regulatory Cell Therapy (TX200-TR101) in a prior clinical study.

This study has been transitioned to CTIS with ID 2024-512580-31-00 check the CTIS register for the current data. PrimaryTo evaluate the long-term safety and tolerability of TX200-TR101 up to 15 years post-TX200-TR101 infusion/baseline.SecondaryTo…

Protein supplementation and exercise training to increase muscle protein synthesis rates in patients with advanced chronic kidney disease

1. To assess whether the skeletal muscle protein fractional synthesis rate as measured by the deuterated water method is different during a 1-week habitual lifestyle period when compared to a 1-week period with resistance-type exercise and protein…

A multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy

This study has been transitioned to CTIS with ID 2023-509331-83-00 check the CTIS register for the current data. Primary objective adults:To demonstrate the superiority of iptacopan (200 mg b.i.d.) compared to placebo in reducing proteinuria at 6…

Frailty in uremia: A survey on the effects of CKD 3-5 on physical functioning and -activity, quality of life and nutritional state

The primary objective of the study is to assess the longitudinal effects of differences and changes in renal function at CKD stage 3-5 on physical functioning. The secondary objectives of the study are to assess the longitudinal effects of…

Determinants of salt taste in healthy volunteers and patients with chronic kidney disease

To compare salt taste and saliva characteristics in healthy volunteers and patients with CKD.

The role of gutmicrobiota composition, epigenetics and autoimmunity in the development and treatment of vasculitis; the VASKIR biobank

Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…

*Randomized controlled prospEctiVe trial comparing extended-release with immediate-release tacrOlimus; reducing calcineurin inhibitor related toxicity in LUng TransplantatION patients*

Primary Objective: to show a reduction in eGFR decline in patients treated with LCP tacrolimus compared to IR tacrolimus. Secondary objectives will include investigating the potential decline in other known side effects of calcineurin inhibitors i.e…

The role of skin sodium accumulation in chronic kidney disease

Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…

Study into the effect of CytoSorb (cytokine adsorber) in relation to the MICrocirculation of patients with Septic Shock and Acute Kidney Injury at the ICU; MICSS-AKI

Could cytokines removal therapy by CytoSorb adsorber cause any improvement in the microcirculation?

MAGnesium In Chronic HemoDialysis; A clinical trial assessing the feasibility of increasing plasma magnesium concentrations by means of increasing dialysate magnesium concentrations in chronic hemodialysis patients.

Main Objective: - Determine feasibility to increase plasma magnesium concentrations in hemodialysis patients by means of increased concentration of magnesium in the dialysate. Secondary Objectives:- Determine safety of increasing plasma magnesium…

DiabetEs Type 2 and thE Role of MacroalbumInuria; a diagnostic tool for vascular ageing with 18F-NaF PET/CT imaging

Primary Objective:To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are increased in patients with T2D who have macroalbuminuria as compared to patients with normoalbuminuria.Secondary…

Blood Outgrowth Endothelial Cells (BOECs) to study endothelial metabolic pathophysiology in diabetes patients.

1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…

Unravelling the mechanism of azoospermia in nephropathic cystinosis

To clarify the mechanism of azoospermia in male cystinosis patientsTo determine the cause of azoospermia in male cystinosis patients as obstructive or non-obstructive by non-invasive means (clinical examination, reproductive hormonal profile,…

Assessment of chronic renal allograft dysfunction with MRI: a pilot study

To investigate whether it is possible to indicate (focal) IF/TA lesions in renal allografts with MRI and compare these findings to the extent of IF/TA in the kidney biopsy that has been taken previously according to current clinical guidelines.

The role of platelets and platelet-derived microvesicles in diabetic nephropathy.

To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.

Is progression of arteriosclerosis in ESRD patients inhibited by nocturnal hemodialysis of renal transplantation?

1. To assess whether nocturnal hemodialysis and renal transplantation give less progression of arterial calcification, compared with conventional hemodialysis and peritoneal dialysis;2. To identify the risk factors for arterial calcification in…

A phase 4, monocenter, randomized, double-blind, comparator-controlled, parallel-group, mechanistic intervention trial to assess the effect of 12-week treatment with the sodium-glucose linked transporters (SGLT)-2 inhibitor dapagliflozin versus the sulfonylurea (SU) derivative gliclazide on renal physiology and biomarkers in metformin-treated patients with type 2 diabetes mellitus (T2DM)

To gain more knowledge about the effects of SGLT2 inhibition on renal hemodynamics and the underlying mechanisms.

The effect of correction of metabolic acidosis in chronic kidney disease on intrarenal RAS activity.

Primary Objective: - To study if sodiumbicarbonate therapy in patients with metabolic acidosis due to chronic kidney disease diminishes intrarenal RAS activity (without affecting the systemic RAS).Secondary Objective(s): - To study if…