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The Most Effective Treatment Strategy for Diabetic Macular Edema.

To demonstrate that combined (repeated) laser photocoagulation prolongs time to failure compared to anti-VEGF monotherapy.

A 2 year randomized, single-masked, multicenter, controlled phase IIIb trial assessing the efficacy and safety of 0.5 mg ranibizumab in two *treat and extend* treatment algorithms vs. 0.5 mg ranibizumab as needed in patients with macular edema and visual Impairment secondary to diabetes mellitus

Primary objective:To demonstrate that the mean change from baseline in Best Corrected Visual Acuity (BCVA) over a 12 month treatment period obtained with either a 0.5 mg ranibizumab *Treat and Extend* (TE) dosing regimen with adjunctive laser, and/…

Clinical Benefits of Color LED Topography in Keratoconus Screening

To demonstrate that CLT is more sensitive for keratoconus detection compared to other corneal topography methods.

Pathogenetic insight in idiopathic orbital inflammation

This study aims to gain insights in the pathogenesis of idiopathic orbital inflammation, with ultimately a directer and more effective therapy.

LATERAL EYELID BLOCK EXCISION VERSUS LATERAL TARSAL STRIP PROCEDURE TO CORRECT FOR HORIZONTAL EYELID LAXITY

To show non-inferiority in success rate of the lateral eyelid block excision compared to the lateral tarsal strip.

Pathogenetic insights in idiopathic orbital inflammation

This study aims to gain insights in the pathogenesis of idiopathic orbital inflammation, with ultimately a directer and more effective therapy.

A prospective randomized intra-individual study concerning the effect of postoperative treatment in blepharoplasty patients: The effect of cold temperature, warmth or pressure on postoperative swelling and haematoma.

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Following RVCL-S to Treatment (FORT) - A natural history study of Retinal Vasculopathy with Cerebral Leukoencephalopathy and Systemic manifestations (RVCL-S)

Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…

Validation and development of new dichoptic VR-gaming method to treat childhood amblyopia; Vedea Amblyopia Therapy (VAT)

The VAT project is set out to prove that this approach is superior and that the Quality of Life of children with amblyopia might be significantly improved in comparison to occlusion therapy.

The effect of lidocaine temperature on pain perception during infiltration for upper blepharoplasty: a blinded randomised trial comparing 21°C and 32°C solutions

To evaluate the effect of lidocaine temperature on pain perception during infiltration for upper blepharoplasty.

A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques. Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK)

To demonstrate that DMEK is superior to DSAEK with respect to visual acuity and quality of vision.

Long-term effects of preterm birth and retinopathy of prematurity on anatomy and functionality of the eye in adults

Primary Objective: Compare visual acuity between adults born prematurely and adults of general population born at full term.Secondary Objective(s): o Compare other anatomical and functional ocular outcomes (retina, macula thickness, refraction,…

High-field MRI of the compression of the anterior visual pathway in pituitary adenoma

Primary Objectives: - Assess the feasibility and clinical value of 7T MR to provide a more detailed anatomic description of the anterior visual pathway in NFMA patients compared to conventional MRI. - Assess the feasibility of high-field MRI to…