72 results
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
The main objective of the study is to gain insight into the cost-effectiveness of BPR compared to care as usual (CAU) for patients withSMI who have a wish for change in their societal participation. Research questions:1. Is BPR (cost-)effective…
1.Social CognitiveA.Do schizophrenia patients, compared to unaffected controls, show impaired social cognition (perceiving, understanding, intentions and emotions of others), especially when it comes to self-other distinction processes (…
The primary aim of this study is to examine whether TAU plus MBT-P has a more positive effect on social functioning than TAU only.Secondly it will be examined whether this potential therapeutic effect is driven by an increase in social cognitive…
Primary ObjectiveIn preparation for a multicentre RCT we want to test the VR SCT for people with psychotic disorders in a feasibility study. We want to evaluate the feasibility and acceptability of VR SCT and improve the intervention protocol using…
Primary Objective: The aim of this study is to determine the time to all-cause discontinuation of penfluridol (acemap; oral long acting neuroleptic) as compared to second-generation oral neuroleptics (olanzapine, risperidone) using an open label…
Primary objective is to compare all cause discontinuation rates in patients with schizophrenia randomized to either one of the two depot medications (aripiprazole depot or paliperidone palmitate) with patients randomized to either one of the two…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The main goal of the study is to develop and validate a device that provides an objective measure of degradation of motor performance in elderly people. The device will assist to diagnose neurodegenerative disorders in the elderly at an early stage…
To examine whether symptoms of dissociation in schizophrenia are qualitatively similar or different to symptoms of dissociation in dissociative disorders.
The effect of Eye Movement Desensitization and Reprocessing on Psychosis: A multiple baseline study.
This study will examine the effectiveness of EMDR in the treatment of psychosis, in patients without PTSD. Primary objective of this study is a first exploration of the efficacy of EMDR in the reduction of psychotic symptoms, perceived power of…
The objectives of this proposal are twofold. First, we intend to test the feasibility of the new concurrent fMRI/TMS setup on real brains of a small group of healthy volunteers. That is, can we indeed evoke fMRI BOLD responses in several functional…
The two primary objectives of this study are:(1) to explore whether UHR in adolescence is associated with neurobiological differences at baseline and/or changes in the course of 4-8 year of follow-up as measured using MR-techniques and compared with…
The goal of the present study is to gain understanding of the brain mechanisms underlying the impairment of multisensory integration processes in schizophrenia. The study will support the development of more precise criteria for the diagnosis of…
Aim of this proposal is to unravel the changes in functional neural networks in healthy human brain and in schizophrenia at 7T. We hypothesize a difference in brain changes between healthy individuals and patients with schizophrenia and abnormal…
We aim to answer the following research questions: 1. Is there an association between trauma and psychopathology in children? In answering this question we will compare cases to their healthy siblings, cases to controls, and siblings to controls. 2…
The following hypotheses are tested in the current study: 1) Metacognitive training is more effective than the standard treatment (TAU) for changing paranoid thinking in patients with psychotic disorders. Subhypothesis: 1a) Metacognitive training is…
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
The goal of the proposed work is to understand dysfunction in two components of cognitive control in schizophrenia: response inhibition and monitoring. The aims of this project are to behaviourally characterize response inhibition and monitoring…
The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…