12 results
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
1.Social CognitiveA.Do schizophrenia patients, compared to unaffected controls, show impaired social cognition (perceiving, understanding, intentions and emotions of others), especially when it comes to self-other distinction processes (…
The aim of this project is to elucidate the mechanisms underlying one of the most incapacitating psychiatric disorders, psychosis. Despite antipsychotic treatment, up to a third of patients with psychotic illness continue to experience significant…
The aim of the current study is to investigate which gene-abnormalities can be related to brain deficits and symptoms associated with schizophrenia.
The aim of the proposed research is to test the hypothesis that lack of insight in psychosis is associated with reduced activation of brain circuits subserving self-evaluation and emotion regulation and that this relationship is also dependent on…
To investigate whether patients with schizophrenia show reliable and consistent brain activations as measured with fMRI to two different stimulation paradigms and wether they differ in terms of the patterns or the intensity of activation as compared…
This study looks if the third generation antipsychotic aripiprazole can improve activity of the prefrontal cortex and cognitive and social function, when compared to the second generation antipsychotic risperidone.
The aim of this study is to investigate the neural correlates of different types of emotion regulation and emotional processing underlying social cognition.
This study will investigate the effectiveness of an interactive smart phone application that provides medication reminders and motivation to take up healthy activities during daily life, with the aim to improve schizophrenic and non-affective…
The aim of the proposed study is to investigate the presence of dopaminergic abnormalities in relation to apathy in persons with a high risk for psychosis. Second, we intend to explore the relation between the dopamine system and apathy in general,…
The aim of the proposed study is to investigate the presence of dopaminergic abnormalities, as measured with [11C]raclopride, in relation to antipsychotic medication discontinuation in patients remitted after a first-episode psychosis (FEP).…
This study aims to investigate if and how synaptic density may underlie cognitive deficits and whether functional connectivity is the intermediate step. In patients with psychotic disorders, cognitive function and brain connectivity may be decreased…