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CD4+ T cells and immune ageing; major players and predictors for disease activity in giant cell arteritis

Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…

Control of breathing in systemic sclerosis

-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…

Scleroderma target discovery

Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…

Genetic origin of Dupuytren*s disease and associated fibromatosis

The purpose of this study is to further unravel the genetic origin of these individual diseases and their relation at genes level.

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a primary Dupuytren*s contracture with standard fasciectomy surgery on convalescence, contracture correction and recurrence rate.

To compare treatment of primary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

The Ehlers-Danlos syndrome and regional anesthesia

Aim of this study is measuring the effects of locoregional anaesthesia in EDS patients and comparing these effects with those in a healthy control group. The results of this study can be used to make a more valid choice for the type of anaesthesia…

COLPOP
'"Collagen metabolism in patients with and without Pelvic Organ Prolapse; a pilot study*

To investigate the collagen metabolism in pelvic floor tissue, pelvic floor-derived fibroblasts, and adipose tissue stem cells in patients with and without pelvic organ prolapse (POP)

Alveolar ridge preservation with a xenograft Bio-Oss Collagen) and a collagen matrix (Mucograft Seal) or a free connective tissue graft versus spontaneous healing: a 1-year prospective randomized clinical study

To evaluate clinical and esthetic outcomes and patient satisfaction following single-tooth replacement in the anterior maxilla in patients treated with a collagen matrix (Geistlich Mucograft® Seal) and a free connective tissue graft versus…

Upfront autologous hematopoietic stem cell transplantation versus immunosuppressive medication in early diffuse cutaneous systemic sclerosis: an international multicentre, open-label, randomized controlled trial

This study has been transitioned to CTIS with ID 2023-505877-34-00 check the CTIS register for the current data. To determine the optimal treatment strategy in early dcSSc: the effect of HSCT as upfront therapy compared with that of…

Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas; a randomized phase II clinical trial

to compare the short-term toxicity of the conventional schedule of 25 x 2 Gy, once daily fractionation in a five-week Overall Treatment Time (OTT) to 14 x 3 Gy, once daily fractionation in a three-week OTT, with respect to the rate of postoperative…

Assessing the frequency, phenotype and function of plasmacytoid dendritic cells and T cells in blood and skin of patients with skin fibrosing disorders

To investigate the difference in number, phenotype and function of plasmacytoid dendritic cells and T cells in and between patients with SSc, LS and EF and between patients with these diseases and healthy controls / patients with psoriasis.