88 results
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…
To determine the effect of hypoglycaemia on BAT-activity.
In subjects with T2DM with inadequate glycemic control on combination therapy withmetformin and an SU:Primary:* To assess the effect of the addition of treatment with canagliflozin compared with theaddition of treatment with sitagliptin on HbA1c…
1) Prevalence of celiac disease in a Dutch cohort of adult type 1 diabetes patients. 2) Investigation of the long term complications of type 1 diabetes patients with concomitant celiac disease
The first objective is to examine the impact of 4-month walking training on physical fitness, insulin resistance and cardiovascular risks in T2DM and their controls and to assess whether these effects are preserved 3 months after cessation of the…
1. Does general anesthesia affect autonomic sympathetic control of coronary blood flow in healthy subjects?2. Does acute inhibition of autonomic sympathetic innervation by means of a thoracic epidural or a thoracic sympathectomy additionally impair…
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
1) To investigate the impact of keeping/loosing diabetes on quality of life and psychological well-being in a group of (morbidly) obese patients who underwent bariatric surgery, and 2) To explore whether we can predict postoperative quality of life…
To investigate whether SAF is elevated in GDM versus non-diabetic pregnancy To investigate whther SAF levels change during the course of normal and GDM pregnancy To investigate if SAF is related to other parameters of hyperglycemia (HbA1c, self…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
To study the impact of laser photocoagulation on the parafoveal visual field in a previously untreated population of patients with DME.
To evaluate the prevalence of advanced ovarian ageing in cycling DM-1 patients using ovarian reserve (OR) testing. To assess the mean age at natural menopause and its variation in DM-1 patients. To study the role of vascular factors in relation to…
Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…
The main objective of the study is to quantify mitochondrial dysfunction in vivo and obtain information of molecular scale adaptations of the muscle cells that potentially underlie the observed dysfunction. The mathematical model will be applied to…
In this RCT we combine cognitive behavioural therapy (CBT) with a maintenance contract and a specific diet (very low calorie diet), to obtain and maintain favourable effects on weight and risk profile over the long term.
The primary aim of this study is to assess the impact of prolonged walking on fluid- and electrolyte balance in 32 patients with T2DM, compared with a matched group of 32 healthy control subjects, and 32 patients with T1DM, during the Nijmegen Four…
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
Primary Objective: To determine whether a four week treatment with vildagliptin compared to acarbose improves endothelial dysfunction in patients with type 2 diabetes mellitus.Secondary Objective(s):-To determine the effect of vildagliptin on plasma…