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Consequences of (recurrent) hypoglycaemia on cardiovascular and inflammatory responses in patients with diabetes mellictus type 1, type 2 and healthy volunteers

Primary objective:* To investigate the consequences of (recurrent) hypoglycaemia on inflammatory responsesSecondary objectives:* To study the atherogenic consequences of (recurrent) hypoglycaemia* To study the molecular mechanisms involved in the…

Blood Outgrowth Endothelial Cells (BOECs) to study endothelial metabolic pathophysiology in diabetes patients.

1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…

The role of platelets and platelet-derived microvesicles in diabetic nephropathy.

To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.

Innovative cardiac MRI in growing high-risk populations to improve outcome

This study aims to better diagnose cardiomyopathy in the increasing high-risk populations of chronic hypertension, type two diabetes mellitus, and obesity/overweight by providing gender specific cardiac MRI cut-off values for cardiac volumes,…

ARNI-study: ARNI or ARB to arrest progression of nephropathy.

To compare the antiproteinuric effects of sacubitril/valsartan (ARNI) and valsartan (ARB).

Diabetes and WELLbeing

Decrease disease-burden in the diabetes type 2 population, by improving quality of life, physical activity levels, physical performance and the overall quality of diabetes care. Thereby empowering the diabetes population to better self-manage their…

A Phase 3b, Randomized, Active Comparator, Open-label, Multicenter Study to Compare the Efficacy, Safety, and Tolerability of ITCA 650 to Empagliflozin and to Glimepiride as Add-on Therapy to Metformin in Patients with Type 2 Diabetes

Primary Objective • To determine whether ITCA 650 is non-inferior either to empagliflozin or to glimepiride in reducing glycosylated hemoglobin A1c (HbA1c) or weight in patients with T2D following 65 weeks of treatment. The non-inferiority margins…

QUANtification of Cardiovascular Autonomic Neuropathy (CAN) and the effects of anaesthesia on hemodynamics and cerebral perfusion

1) To study whether peri-operative haemodynamics fluctuate more in patients with DM2 and CAN. 2) To study whether CAN further worsens cerebral perfusion in addition to impaired CA.