258 results
We aim to assess the impact of 12-week BG supplementation on blood glucose levels in subjects with impaired fasting glucose levels.
To evaluate the safety and performance of the Digma System for duodenal submucosal ablation in patients with type 2 diabetes in comparison to baseline and to sham control.
The aim is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with IFG and IGT when compared to healthy, non-diabetic, overweight participants. In addition, it will be investigated if reducing…
This study consists of the following objections:- To evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham)- To evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks (compared…
To determine the long-term clinical effectiveness of treatment with a dual-hormone (insulin and glucagon) fully closed loop system during 12 months compared to the current most used care and to the currently most advanced technological care.…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
Primary Objective: 1. What is the difference in effectiveness of Early Time-restricted Eating (eTRE) in glycaemic regulation when compared to isocaloric continues caloric restriction (CCR) after one year in overweight adults with type 2 diabetes?…
To determine the role of dietary BCAA ingestion and omittance on MPS and insulin sensitivity
To determine the long-term clinical effectiveness of treatment with a dual-hormone (insulin and glucagon) fully closed loop system during 12 months compared to the current most used care and to the currently most advanced technological care.…
Primary Objective: to determine the activity rhythm of the SCN in humans with progressive stages of insulin resistanceSecondary Objective(s): to determine the daily rhythm of the peripheral clock in buccal cells in humans with progressive stages of…
The objective of this first-in-human study is to evaluate the safety, feasibility and efficacy of Re-Cellularization via Electroporation Therapy (ReCET) by the (Endogenex system) combined with (GLP-1 receptor agonist) in subjects with insulin…
Assess the safety and tolerability of the EcNΔClbP strain relative to the EcN wildtype strain following a 1-week daily administration, through questionnaires, medical examination and measurement of inflammatory markers.
The primary objective of this study is to evaluate the efficacy of endoscopic sutured gastroplasty with the endomina device (EndoTools Therapeutics S.A.) on glycemic control (reduction in insulin dose), in obese insulin treated type 2 diabetes…
This study has been transitioned to CTIS with ID 2024-519386-21-00 check the CTIS register for the current data. The central aim of the POEM Study: to investigate whether the early start of metformin on top of standard care may improve the treatment…
To compare in diabetic patients eligible for percutaneous coronary intervention (PCI) with minimal exclusion criteria, the efficacy and safety of Abluminus/Abluminus DES+ sirolimus-eluting stents (SES) versus XIENCE Everolimus-Eluting Stents (EES).…
The objective of this study is to find out whether a 150cm BPL-length OAGB is just as good in treating morbidly obese adults when compared to a 150cm BPL-length RYGB with a 75cm Roux-limb in terms of percentage excess BMI loss and nutritional…
The objective of the study is to assess whether the postprandial glucose response of the adapted product is equivalent to the postprandial glucose response of the original product.
The main objective is to determine the efficacy of Lyumjev in the Inreda AP system. Secondary objectives are: to assess safety, differences in pharmacodynamics and differences in AP-related outcome measures.
To study the potential of the daily use of a mini-trampoline or metformin added to the NHG -guided lifestyle to cure early type 2 diabetes in overweight and obese patients. PICO research question. What is the effect of the mini-trampoline or…
Primary objective: to assess and compare the effect of lean-donor phage transplantation with placebo treatment (PBS) on glucose tolerance in obese, insulin resistant subjects at risk to develop diabetes. Secondary objective: to assess and compare…