258 results
The objective of the study is to evaluate the (cost-)effectiveness of a stepped-care approach starting with HypoAware, compared with CGM in type 1 diabetes patients with an impaired awareness of hypoglycemia.
To investigate whether fecal microbial transplantation (FMT) from either allogenic (individuals with type 1 diabetes and a highly preserved beta cell fraction) or autologous (own) donor, administered every 8 weeks during 6 months through a small…
this research answers the need to evaluate whether the 780G hybrid closed-loop system in pregnant women with T1DM can improve glycaemic control with less hypoglycaemia. This in turn, might improve pregnancy outcomes in women with T1DM.
We would like to investigate if use of donor FMT enriched desulfovibrio bacterial strains has a beneficial effect on gut microbiota diversity and subsequent improvement of (diet derived) fructose catabolism and insulin sensitivity in patients with…
Primary Objective: Compare the uptake of 68Ga-NODAGA-exendin-4 in the liver between T1D patients with functional islet grafts (C-peptide > 0.8 nmol/L after mixed meal stimulation test and relevant laboratory parameters as HbA1C and exogenous…
To evaluate the long-term effects of GH-therapy on metabolic profile and risk factors for cardiovascular diseases in adults (aged 25-35 years) born SGA and compare this with non-treated adults born SGA and with adults born AGA.
Primary Objective: To evaluate the effects of LRYGB with subtotal gastrectomy (LRYGB+) as compared to standard LRYGB (LRYGB-) on striatal D2/D3 receptor availability and dopamine release as well as on whole brain serotonergic activity. Secondary…
Primary objective: To evaluate the effect of treatment with oral hypoglycemic agents (OHA) on the incidence of large-for-gestational-age (LGA) infants in women with GDM requiring medication, compared to insulin (INS) treatment.Secondary objectives:…
The study objective is to measure beta cell mass and function in subjects with type 1 diabetes during and shortly after the honeymoon phase, to determine whether the change in metabolic control is mainly caused by a decrease in the total number of…
The current study will investigate whether the FSL can be used to establish the diagnosis GDM in women who became pregnant after bariatric surgery. To accomplish this, first it will be necessary to gain insight into the continuous glucose pattern of…
The objective of this study is to measure the postprandial glycemic response to several nutritional products.
The aim of the proposed study is to screen for (pre)DM, an increased 10-year-risk of ASCVD, MetS and a high risk of OSAS in subjects with and without periodontitis. Consequently, the dental office will be evaluated as a suitable location for early…
The aim of the present study is to examine the interaction (and underlying mechanisms) between hepatic fructose and glucose metabolism in humans. The first objective is to determine the dose-effect relationship between oral fructose and the plasma…
Primary Objective: to compare the effects of two interventions on lifestyle behaviour (food intake and physical activity) and quality of life in people with T2DM. The interventions include the National Diabetes Challenge (*NDC-only group*), and a…
The current study aims to compare skeletal muscle glucose uptake after 1) an exercise stimulus and 2) under hyperinsulinemic conditions between CML patients on nilotinib, CML patients on imatinib and non-CML controls.
We hypothesize that improving sleep will improve glycaemic control in people with T2DM and insomnia. To test this hypothesis, we established the following objectives: 1) investigate if improving sleep by internet-based cognitive behavioural therapy…
The purpose of this explorative study is to investigate whether treatment with lactate has any positive effect on the symptoms of GLUT1DS, especially the drug-resistant epilepsy.Primary Objective: - To assess changes in EEG during and shortly after…
The main study objective is to measure residual beta cell mass, indicated by the pancreatic uptake of Ga-68-exendin using quantitative PET, in type 1 diabetes patients with stable near-normal and unstable glucose control, to improve understanding of…
Primary Objective To demonstrate that ICS can be safely withdrawn in T2-low asthma patients with obesity in secondary care (i.e. without loss of asthma control).Secondary Objectives1. To determine predictive factors for successful ICS withdrawal.2.…
Primary objectiveTo demonstrate the effect on glycaemic control of once weekly insulin icodec in combination with insulin aspart, with or without non-insulin anti-diabetic drugs, in subjects with T2D on a basal-bolus regimen. This includes comparing…