258 results
Primary Objective: Compare achievement of glycemic control in SSI therapy and NPH insulinGlycemic control is defined as the proportion of glucose measurements within target range (Fasting target glucose 3.9 * 7.8 mmol/l. Random target glucose 3.9-10…
Primary Objectives: 1. To tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in MELAS patients.2. To investigate which cerebral biomarkers are shared and differ between MELAS…
Primary objective: What are the long-term effects (i.e. after 8-week drug exposure) of the DPP-4i linagliptin versus the SU derivative glimepiride on fasting and postprandial renal hemodynamics (glomerular filtration rate (GFR)/ effective renal…
The purpose of this studie is to evaluate the bioequivalence of canagliflozin.
To investigate whether bacterial translocation to pancreatic beta cells is increased in type 2 diabetes mellitus patients. Moreover, we will study which bacterial strains are involved translocation. Finally, we will obtain and culture beta cells to…
To study the effect of a Mediterranean diet (MD) followed by lean donor fecal microbiota transplantation (FMT) versus the prescription of Mediterranean diet (MD) followed by autologous (own) FMT in male subjects with metabolic syndrome on peripheral…
Primary objective: Assessment of the impact of the reference glucose measurement on the measured performance of a CGM system, comparing regular venous and arterialized-venous reference glucose samples.Secondary objective: - Assessment of the impact…
To examine the effects of mono- and combination therapy with linagliptin and empagliflozine on renal hemodynamics
The primary objective is to investigate whether Kori-tofu protein affects postprandial blood glucose concentrations, when administered as a part of an ordinary high carbohydrate meal. The secondary objective is to investigate whether Kori-tofu…
We aim to assess the impact of 4-week BG supplementation on blood glucose levels and glucose tolerance in subjects with an impaired fasting glucose or with an impaired glucose tolerance. In addition we will evaluate how BG supplements modulate…
To examine the effect of two different degludec dose adjustments on glucose profiles and the incidence of (nocturnal) hypoglycaemia after oxidative exercise in people with DM1 at elevated risk of hypoglycaemia.
The objective of this project is to study the effects of low levels of dietary AGEs in overweight subjects on insulin sensitivity, *-cell function, micro- and macrovascular function, and gut microbiota. The obtained insights can be used to attenuate…
Primary objective is to evaluate and compare the glycaemic control in T2DM within the first year of LRYGB and LMBG. Secondary aim is to gain insight in the pathophysiological mechanisms that drive the conversion of malign to benign obesity.
The main study objective is to examine the effect of the PTWD program on glycaemic control of lower-educated participants with T2D. The secondary objectives include the effect on medication use, use of care and T2D self-management behaviours. We…
The primary objective is to investigate the potential benefit of scheduled natural daylight exposure to improve glucose control in T2DM individuals and to unravel molecular mechanisms underlying effects of natural daylight on circadian clocks and (…
The study objective is to compare the pituitary uptake of 68Ga-NODAGA-exendin in patients with and without adequate response (based on HbA1c or weight loss or classification by the treating diabetologist) to GLP-1R agonist treatment, to increase…
Primary Aim: We aim to determine markers for NOX2-mediated insulin-independent glucose uptake signalling pathways, mitochondrial function, myokine secretion both at rest and after a bout of acute exercise in individuals with T1DM and healthy…
To assess the efficacy of Revita® DMR for improving HbA1c to <= 7% without the need of insulin in subjects with T2D compared to sham.To assess the efficacy of DMR versus Sham on improvement in Glycemic, Hepatic and Cardiovascular endpoints.
Primary Objective:• To evaluate the effect of an online 12 week plant-based dietary program compared to usual diet on change in glycated hemoglobin and estimated relative CVD risk in persons with type 2 diabetes. Secondary Objective(s): • To…
To perform a patient satisfaction study on the Equil patch pump in T1DM patients that currently already use CSII in combination with CGM or Flash glucose monitoring.