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Among IVF patients undergoing fixed antagonist protocols with recombinant FSH, does administration of recombinant FSH from cycle day 5 onwards compared with cycle day 2 onwards, yield a higher number of good quality embryos?

The aim of the study is to determine whether cycle day (CD) 5 start of stimulation will lead to better quality of embryos, based on morphology, than CD 2 start, in IVF with GnRH antagonist co-treatment started on a fixed day.

TOPFIT: Triptorelin Oral contraceptive Pill Flare-up in IVF/ICSI Treatment trial
The effect of a short, flare-up gonadotrophin-releasing hormone agonist versus antagonist treatment protocol in patients pre-treated with oral contraceptive pill on premature luteinizing hormone surges

The aim of the study is to show non-inferiority of a short, flare-up GnRH-agonist protocol to the GnRH-antagonist protocol, both with OC pill pre-treatment, in women undergoing in vitro fertilisation (IVF) or intracellular sperm injection (ICSI)…

A randomised controlled trial comparing in vitro maturation of oocytes with in vitro fertilisation in women with an increased risk of ovarian hyperstimulation syndrome.

Primary objective: To evaluate the cumulative live birth rate for two treatment strategies: 2 IVM/ICSI cycles versus 1 COH/IVF or COH/ICSI cycle.Secondary Objectives: To evaluate the health and development of IVM/ICSI children versus COH/IVF/ICSI…

TREATMENT ALTERNATIVES FOR SUBFERTILE WOMEN WITH CLASS II ANOVULATION NOT CONCEIVING AFTER SIX OVULATORY CYCLES WITH CLOMIPHENE CITRATE

The purpose of this study is to assess the effectiveness of extended treatment with CC compared to treatment with gonadotropins and/or the use of intra-uterine insemination, in patients who had six ovulatory cycles after CC, but did not conceive.

Implantation failure as a cause of unexplained infertility; determinants of the successrate in ART in women with unexplained infertility.

We will assess the correlation between the incidence of early pregnancy loss and the successrate of ART in women with unexplained infertility. We will also investigate the difference in the incidence of early pregnancy loss in women with unexplained…

A phase IV prospective, multicentre, randomized, open-label trial to assess the efficacy and safety of GONAL f® at a dose based on subject baseline characteristics determined according to the CONSORT calculator compared with a standard dose of GONAL f® 150 IU per day for ovarian stimulation in women undergoing assisted reproductive technology (ART)

The purpose of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered a GONAL-f® dose determined according to a calculator system versus a given standard GONAL-f® dose of 150 International Unit…

SIMULTANEOUS MEASUREMENT OF PELVIC FLOOR ACTIVITY, VAGINAL PLETHYSMOGRAPHY AND VAGINAL INNERVATION IN WOMEN WITH AND WITHOUT HYPERACTIVE PELVIC FLOOR SYNDROME.

The purpose of this study is to investigate whether the hyperactive pelvic floor syndrome can be assessed by objective measurement. This will be done by means of a newly developed instrument, the so-called VPA/EMG/sensibility-combiprobe, that…

Super ovulation in Intra uterine insemination: FSH or Clomifene citrate? The Super Trial.

To determine which ovarian hyperstimulation regimen (FSH or CC) should be applied in IUI in couples with unexplained subfertility or mild male factor subfertility.

TREATMENT ALTERNATIVES FOR SUBFERTILE WOMEN WITH CLASS II ANOVULATION NOT CONCEIVING AFTER SIX OVULATORY CYCLES WITH CLOMIPHENE CITRATE

The purpose of this study is to assess the effectiveness of extended treatment with CC compared to treatment with gonadotropins and/or the use of intra-uterine insemination (IUI), in patients who had six ovulatory cycles after CC, but did not…

The freeze-all strategy in IVF: who benefits?

To test the hypothesis that in women undergoing IVF/ICSI a freeze-all strategy results in higher ongoing pregnancy rates and is more cost-effective compared to a fresh embryo transfer.

Longitudinal follow up of serum anti-Müllerian hormone levels in women with rheumatoid arthritis

The objective of this study is to investigate the intra-individual change in AMH levels over several years in female RA patients.

An online fertility workup for sub-fertile couples

Primary Objective: The aim of this study is to compare if an online consultation with diagnostic testing during a fertility workup, is as effective as a regular consultation in terms of patient centeredness, shared decision making and costs.

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project (DCOG LATER study)
DCOG LATER substudy: Sexual function and psychosexual development in long-term childhood cancer survivors

This DCOG-LATER project proposal aims to characterize the overall, disease and treatment-related risks of sexual dysfunction and delays in psychosexual development in a Dutch cohort of 5-year CCS treated in the period 1960-2001 and to evaluate the…

A randomised, controlled, open label, parallel group, multicentre trial comparing the efficacy and safety of individualised FE 999049 (follitropin delta) dosing, using a long GnRH agonist protocol and a GnRH antagonist protocol in women undergoing controlled ovarian stimulation

primary objective:To evaluate the effect of individualised FE 999049 treatment on ovarian response in a long GnRH agonist protocol versus a GnRH antagonist protocolSecondary objectives:* To evaluate the effect of individualised FE 999049 treatment…

Does endometrial scratching increase the rate of spontaneous conception in couples
with unexplained infertility and a good prognosis (Hunault >30%)?

To asses whether endometrial scratching increases live birth rates in couples with unexplained infertility and a good prognosis (Hunault>30%)?

PEnile ReHAbilitation After Nerve Sparing Robot-assisted Radical Prostatectomy for Prostate Cancer 2.0, a Multicenter, Randomized Clinical Trial

This study aims to assess the effect of two different rehabilitation strategies on the recovery rate of ED after nsRP in patients who undergo nsRP.

Continuous use of Oral contraceptives as an alternative for long term Pituitary down-regulation with a GnRH agonist prior to IVF/ICSI in Endometriosis patients: a randomised controlled trial and prospective cohort study

To show a non-inferiority of continuous use of oral contraceptives for three months to long term pituitary down-regulation with a GnRH agonist for three months prior to present-day IVF/ICSI protocols in patients with severe endometriosis (ASRM…

MURIM: MUltidisciplinary Research on Implantation failure and Miscarriage

The goal of this study is to elucidate whether there is a difference in endometrial parameters (determining endometrial receptivity) between women with reproductive failure: RIF and RM. Secondly we will investigate how the endometrial parameters of…

A randomized controlled multicenter trial comparing bariatric surgery with a structured life style intervention program in subfertile obese women with PCOS

It is hypothesed that intervention (bariatric surgery) compared with control (life style intervention program) will increase fertility measured by the healthy born baby rate after at least 37 weeks of gestation (primary end point) within 3 years…

The effect of methotrexate on fertility parameters in men with immune mediated diseases

To determine whether MTX can be quantified in seminal plasma and spermatozoa of MTX-naïve and chronic-MTX users, and to compare the concentration of MTX in seminal fluid and spermatozoa between MTX-naïve users and chronic-MTX users and to evaluate…