819 results
Isolation of skin fibroblasts from MS patients for reprogramming into induced pluripotent stem cells
In this study we aim to address the hypothesis that oligodendrocytes and oligodendrocyte precursor cells from MS patients exhibit epigenetically determined differences in protein expression profiles and functional behavior in comparison to those…
Gain insight in the anatomy and organisation of the sacral plexus in children with NB and congenital spinal or sacral anomalies. Possible findings can be compared with the results of the healthy subjects, in order to be able to relate findings to…
Primary:To investigate the presence of disease-specific antimyenteric antibodies and to identify their target-antigen in patients with achalasia.Secondary:- To determine to what extent humoral autoimmunity is the etiological factor in idiopathic…
The primary objective is to evaluate the effectiveness of low-intensity hand rim wheelchair exercise training on physical capacity, daily (wheelchair) functioning, participation and quality of life in people with a spinal cord injury. Furthermore,…
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
In this study, we will systematically investigate the influence of distractors on target processing in patients with lesions to the frontal, parietal and occipital system. This will be measured by eye movements. Furthermore, prism adaptation will be…
The primary objective is to determine whether neuroinflammation is present in subjects who have been exposed to chronic repetitive head injury during Muay Thai boxing, using [11C]-PK11195 PET.
To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.
To investigate which technique is the most effective in terms of pain relief on short term in patients with contained cervical disc herniation: PCN or PRF?
To assess in a pilot setting whether there are differences (including sensitivity and specificity) in pen motion, grip force patterns and muscle activity, derived using a newly developed system for handwriting monitoring, between A: patients with…
The primary goal of this study is to develop a protocol for future studies in patients after a first seizure. We investigate 3 methodological aspects. - What is the effect on the auditory evoked potential of different types of noise masking?- What…
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
The purpose of this study is to investigate the clinical effectiveness of a self management group intervention for stroke patients with social reintegration problems and their partners compared to a control group education intervention. The main…
The aim of this prospective study is to elucidate whether copeptin could be used as a marker for prognosis and severity of aSAH in a Dutch intensive care population?
What is the long-term clinical benefit of best medical practice with and without adjunctive SCS Therapy in patients with chronic diabetic neuropathic pain?
The primary objective of this study is to determine if neuroinflammation is present in patients with mild traumatic brain injury, using [11C]-PK11195 PET. The secondary objective is to determine if there is a correlation between [11C]-PK11195…
We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…
Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.
Primary: To study whether there is a difference in treatment effect between oxygen at flow rates of 7 L/min versus 12 L/min in the acute treatment of cluster headache attacks. Secondary: - Identifying subgroups in which oxygen at flow rates of 7 L/…
The aim of the proposed *proof-of-principle* study is to assess the feasibility and (preliminary) effectiveness of a newly developed 5-week perturbation-based training program using the Radboud Falls Simulator (RFS) on dynamic balance capacity in…