819 results
There is at present a major focus on the role of the cerebellum in the pathophysiology of dystonia. It is speculated that the cerebellum is an hitherto overlooked yet fundamental part of the abnormal sensorimotor network that drives dystonia. This…
To compare the effect of a stimulus rich context, specifically developed for rehabilitation (rehab game), with a less rich context (conventional exercises) during reach training for restoration of arm function in chronic stroke patients.
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
The project has two principal aims: (1) to assess the relative effectiveness of the three interventions, also as a function of patient characteristics, and (2) to delineate the functional and neurophysiological changes that are associated with those…
The aim of the proposed study is to get more insight into the role of the hippocampus and thalamus in cognitive impairment in MS patients. To achieve our goal, we propose to study the (abnormal) structure and function of the two structures with…
Does adjustment of medication intake time to the individual circadian rhythm improve effects of AEDs?
The primary aim of this study is to evaluate the effects of a structured, progressive task-oriented fitness training program applied in a group of 8 to 10 patients on perceived outcome of mobility after stroke when compared to individually-tailored…
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
The main question in the study isHow do moderately preterm infants and their parents differ from term, as well as extreme preterm infants in (a) development and self regulation skills of the infants, (b) interaction patterns and relationship between…
The aim of this study is to investigate the effect of a MSE intervention on social participation and quality of life in chronic stroke patients. This MSE intervention will be compared to a controlgroup in order to measure the additional effect of…
The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…
We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…
Cytotoxic treatment may lead to long-lasting brain damage that can result in persistent cognitive changes and accelerated cognitive decline at an older age. The proposed study will investigate whether chemotherapy causes brain changes different from…
Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.
The study objective is to evaluate, with respect to hand function, the effect of a physical therapy program based on mirror therapy compared to conventional physical therapy in chronic stroke patients and to improve our understanding of the…
To measure the effectiveness of intrathecal methylprednisolone and lidocaine on reducing PHN. Measurement of mthylprednisolone concentrations in cerebrospinal fluid (Part I only).
Firstly, to investigate whether the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in patients who are being pre-treated with either a 300 mg or a 600 mg loading dose…
- To assess the usefulness of 5-HT phMRI (BOLD-, PWI and ASL based phMRI) in assessing cerebral 5-HT neurotoxicity when compared to SERT SPECT.- To assess which MRI technique (BOLD-, PWI or ASL) is best in assessing cerebral 5-HT neurotoxicity when…
To investigate the effect of late onset depression and inflammation on the pathological progression from MCI to Alzheimer*s disease by determining the correlation of microglia cell activation, β-amyloid deposition, brain volume, peripheral…
OBJECTIVES: -to assess the usefulness of DA-phMRI (task related fMRI, steady state fMRI and ASL based phMRI) in assessing amphetamine induced DA-neurotoxicity when compared to DAT SPECT.-to assess which MRI technique (task related fMRI, steady state…